3-Chloro-4-methylphenyl isocyanate
3-Chloro-4-methylphenyl isocyanate (CAS 28479-22-3), with the molecular formula ClC6H3(CH3)NCO and a molecular weight of 167.59 g/mol, is a reactive organic intermediate. It serves as a valuable building block in chemical synthesis, particularly for the preparation of complex organic molecules and pharmaceutical intermediates. Its isocyanate functionality allows for facile derivatization into ureas, carbamates, and other nitrogen-containing compounds, making it a key reagent in organic chemistry research and development.
Organic Synthesis Intermediate
Utilised as a key building block in the synthesis of various organic compounds. Its isocyanate group readily reacts with nucleophiles like alcohols and amines to form esters and amides, respectively, enabling the construction of diverse molecular architectures.
Pharmaceutical Intermediate
Serves as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs). It allows for the introduction of specific structural motifs required for biological activity in drug discovery and development.
Material Science Research
Can be employed in the development of novel polymers and materials. The reactive isocyanate moiety facilitates polymerisation reactions or cross-linking processes, leading to materials with tailored properties.
| Molecular weight | 167.59 |
|---|---|
| Linear formula | ClC6H3(CH3)NCO |
| Assay | 98% |
| Boiling point | 107 °C/3 mmHg(lit.) |
| Density | 1.224 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.557(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 109 °C / 228.2 °F |
| Transport (UN / ADR) | UN 2236 6.1 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-42 |
| Safety statements (S) | 23-26-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-4-methylphenyl isocyanate used for?
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3-Chloro-4-methylphenyl isocyanate is primarily used as a building block in organic synthesis, particularly for the preparation of pharmaceutical intermediates and potentially in material science research. Its reactive isocyanate group allows for the formation of ureas and carbamates.
What is the CAS number and formula for 3-Chloro-4-methylphenyl isocyanate?
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The CAS number for 3-Chloro-4-methylphenyl isocyanate is 28479-22-3, and its molecular formula is ClC6H3(CH3)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Chloro-4-methylphenyl isocyanate with an assay of 98%. This product is intended for laboratory and research use and is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should 3-Chloro-4-methylphenyl isocyanate be handled safely?
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3-Chloro-4-methylphenyl isocyanate is classified as dangerous. It is harmful if swallowed, in contact with skin, or if inhaled, causes skin irritation, serious eye irritation, and may cause respiratory irritation and an allergic reaction in a severely. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, must be used. Handle only in a well-ventilated area or under a fume hood. Consult the Safety Data Sheet for full handling and emergency procedures.
How is 3-Chloro-4-methylphenyl isocyanate packed and shipped?
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This compound is packed and shipped according to international regulations for hazardous materials, designated as UN 2236, Class 6.1, Packing Group II. Tech Serve Solutions adheres to all export regulations for safe and compliant global distribution.
How can I request a sample or quote for 3-Chloro-4-methylphenyl isocyanate?
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To request a sample or obtain a quote, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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