3-Chloro-2-butanone
3-Chloro-2-butanone (CAS: 4091-39-8) is an organic compound with the linear formula CH3CHClCOCH3 and a molecular weight of 106.55 g/mol. This halogenated ketone serves as a valuable building block in chemical synthesis. It is primarily utilised in the production of chiral alcohols and in the formation of carbene precursors, offering versatile applications for organic chemists and researchers in various fields.
- IUPAC
- Chloro-MEK
- Synonyms
- Chloro-MEK
Synthesis of Chiral Alcohols
3-Chloro-2-butanone has been employed in the biotransformation of acetophenone derivatives, β-ketoesters, and N-Boc-3-pyrrolidinone into chiral alcohols using recombinant E. coli cells.
Carbene Precursor Synthesis
This compound is utilized in the synthesis of carbene precursors, specifically noted in the preparation of 3-aryl-4,5-dimethylthiazolium chloride.
Organic Synthesis Intermediate
As a functionalised ketone, 3-Chloro-2-butanone acts as a versatile intermediate for introducing specific structural motifs in complex organic molecules.
| Molecular weight | 106.55 |
|---|---|
| Linear formula | CH3CHClCOCH3 |
| Assay | ≥96.0% (GC) |
| Boiling point | 114-117 °C(lit.) |
| Density | 1.055 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.421(lit.) |
| Application | 3-Chloro-2-butanone was used in production of chiral alcohols from acetophenone derivatives, β-ketoesters and N-Boc-3-pyrrolidinone by recombinant E. coli cells1. It was used in the synthesis of carbene precursor, 3-aryl-4,5-dimethylthiazolium chloride2. |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 28 °C / 82.4 °F |
| Transport (UN / ADR) | UN 1224C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-2-butanone used for?
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3-Chloro-2-butanone is used as a building block in chemical synthesis, particularly for producing chiral alcohols from various precursors and in the synthesis of carbene precursors like 3-aryl-4,5-dimethylthiazolium chloride.
What are the CAS number and formula for 3-Chloro-2-butanone?
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The CAS number is 4091-39-8 and the linear formula is CH3CHClCOCH3.
What grade and purity does Tech Serve Solutions supply for 3-Chloro-2-butanone?
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Tech Serve Solutions supplies 3-Chloro-2-butanone with a purity of ≥96.0% (GC). This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
How should 3-Chloro-2-butanone be handled safely?
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3-Chloro-2-butanone is a flammable liquid and vapour (H226) and is harmful if swallowed (H302). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure use in a well-ventilated area away from ignition sources.
Is 3-Chloro-2-butanone a controlled substance?
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The provided data does not indicate that 3-Chloro-2-butanone is a controlled substance.
How is 3-Chloro-2-butanone typically packed and exported?
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3-Chloro-2-butanone is packed and shipped according to international regulations for flammable liquids. As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide.
How can I request a quote or sample for 3-Chloro-2-butanone?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or by calling our main office. Please reference the product name and CAS number.
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