3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine (CAS: 72537-17-8; C6H2ClF4N) is a halogenated pyridine derivative. With a molecular weight of 199.53 g/mol, this compound serves as a valuable building block in organic synthesis. Its structure, featuring a trifluoromethyl group and halogen substituents on the pyridine ring, makes it useful in the development of novel agrochemicals and pharmaceuticals. It is supplied by TSS with an assay of 98%.

Agrochemical Synthesis
This fluorinated pyridine derivative is utilised as an intermediate in the synthesis of novel agrochemicals. The trifluoromethyl and halogen substituents can impart desirable properties to the final active ingredients, influencing efficacy and environmental persistence.
Pharmaceutical Intermediates
The compound is employed in the development of new pharmaceutical agents. Its unique structural features allow for the introduction of specific chemical functionalities, crucial for creating drug candidates with targeted therapeutic actions.
Organic Synthesis Building Block
As a versatile building block, 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is used in various organic transformations. Its reactivity profile enables chemists to construct complex molecules for research and development purposes.
Fluorinated Heterocycle Research
This chemical is of interest in research focused on fluorinated heterocyclic compounds. These structures are often investigated for their potential in medicinal chemistry and material science due to the unique electronic properties imparted by fluorine.
| Molecular weight | 199.53 |
|---|---|
| Empirical formula | C6H2ClF4N |
| Assay | 98% |
| Boiling point | 50-55 °C/11 mmHg(lit.) |
| Density | 1.524 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.433(lit.) |
| Melting point | 16-20 °C(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 52 °C / 125.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine used for?
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3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is primarily used as a building block in organic synthesis, particularly in the development of agrochemicals and pharmaceuticals. Its fluorinated heterocyclic structure makes it valuable for introducing specific functionalities into complex molecules.
What are the CAS number and formula for 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine?
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The CAS number for 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is 72537-17-8, and its empirical formula is C6H2ClF4N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine with an assay of 98%. We do not represent this product as USP, BP, EP or any other pharmacopoeia grade.
What are the primary safety hazards associated with 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine?
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This compound is flammable (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including gloves, eyeshields, and respiratory protection, should be used when handling it.
Is 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine a controlled substance?
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The provided data does not indicate that 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is a controlled substance.
How is 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine packed, shipped, and exported?
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3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is packed, shipped, and exported in compliance with all relevant transportation regulations for hazardous materials, including UN 1993 classification.
How can I request a sample or quote for 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine?
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To request a sample or quote for 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, please contact our sales team through the website or by phone.
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