3-Chloro-2-fluorobenzenesulfonyl chloride
3-Chloro-2-fluorobenzenesulfonyl chloride (CAS: 351003-48-0), with the molecular formula ClC6H3(F)SO2Cl and a molecular weight of 229.06 g/mol, is a specialised aryl fluorinated building block. This compound serves as a key intermediate in organic synthesis, particularly for the introduction of the 3-chloro-2-fluorobenzenesulfonyl group. Its reactive sulfonyl chloride functionality makes it valuable in the preparation of various organic molecules for research and development.

Organic Synthesis Intermediate
Utilised as a building block in the synthesis of complex organic molecules. Its structure allows for diverse chemical modifications, making it a versatile reagent in research laboratories.
Pharmaceutical Research
A key intermediate for the development of novel pharmaceutical compounds. The fluorinated aryl sulfonyl moiety can impart unique properties to drug candidates.
Agrochemical Development
Employed in the synthesis of potential agrochemical agents. The introduction of halogenated aromatic rings is a common strategy in developing new pesticides and herbicides.
Materials Science
Can be used in the development of novel functional materials. The unique electronic and steric properties of the molecule may be leveraged in polymer or specialty chemical research.
| Molecular weight | 229.06 |
|---|---|
| Linear formula | ClC6H3(F)SO2Cl |
| Assay | 97% |
| Density | 1.584 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5540(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-2-fluorobenzenesulfonyl chloride used for?
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3-Chloro-2-fluorobenzenesulfonyl chloride is primarily used as a building block in organic synthesis for the preparation of various chemical compounds, including pharmaceutical intermediates and agrochemicals.
What is the CAS number and molecular formula for 3-Chloro-2-fluorobenzenesulfonyl chloride?
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The CAS number is 351003-48-0 and the molecular formula is ClC6H3(F)SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Chloro-2-fluorobenzenesulfonyl chloride with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3-Chloro-2-fluorobenzenesulfonyl chloride be handled?
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This compound is dangerous and causes severe skin burns and eye damage (H314). Handle with extreme caution, wearing appropriate personal protective equipment including face shields, gloves, goggles, and a suitable respirator. Ensure adequate ventilation. Refer to the Safety Data Sheet (SDS) for detailed handling procedures.
Is 3-Chloro-2-fluorobenzenesulfonyl chloride packed and shipped globally by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3-Chloro-2-fluorobenzenesulfonyl chloride, adhering to international shipping regulations for hazardous materials.
How can I request a quote or sample for 3-Chloro-2-fluorobenzenesulfonyl chloride?
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To request a quote or a sample of 3-Chloro-2-fluorobenzenesulfonyl chloride, please contact our sales department through the website or by calling us directly.
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