3-Acetamidophenol
3-Acetamidophenol (CAS: 621-42-1), also known as 3'-hydroxyacetanilide, is an organic compound with the linear formula CH3CONHC6H4OH and a molecular weight of 151.16 g/mol. This phenol derivative serves as a valuable building block in organic synthesis. It is commonly employed in chemical research and development, particularly in the synthesis of more complex molecules within the pharmaceutical and fine chemical sectors. Its utility lies in its reactive functional groups, making it a versatile intermediate.
- IUPAC
- 3′-Hydroxyacetanilide
- Synonyms
- 3′-HydroxyacetanilideN-(3-Hydroxyphenyl)acetamide3-Hydroxyacetanilidep-Acetamidophenol (incorrect, this is 4-isomer)Metacetamol (incorrect, this is 4-isomer)

Organic Synthesis Intermediate
3-Acetamidophenol is frequently utilised as a precursor or intermediate in the synthesis of various organic compounds. Its phenolic hydroxyl group and acetamide moiety allow for diverse chemical transformations.
Research and Development
This compound is an important reagent in laboratory settings for academic and industrial research. It aids in the development of novel compounds and exploration of new synthetic pathways.
Pharmaceutical Building Block
As a key building block, 3-Acetamidophenol plays a role in the multi-step synthesis of active pharmaceutical ingredients (APIs) and related molecules.
| Molecular weight | 151.16 |
|---|---|
| Linear formula | CH3CONHC6H4OH |
| Assay | 97% |
| Melting point | 145-148 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Acetamidophenol used for?
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3-Acetamidophenol is primarily used as a building block in organic synthesis and in research and development for the creation of more complex molecules, including potential pharmaceutical intermediates.
What are the CAS number and formula for 3-Acetamidophenol?
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The CAS number for 3-Acetamidophenol is 621-42-1, and its linear formula is CH3CONHC6H4OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Acetamidophenol with an assay of 97%. This product is typically intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should 3-Acetamidophenol be handled?
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3-Acetamidophenol is classified with GHS07 warning signal. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask type N95 (US). Ensure adequate ventilation and avoid breathing dust.
How is 3-Acetamidophenol packed and shipped?
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3-Acetamidophenol is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for 3-Acetamidophenol?
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To request a sample or a quote for 3-Acetamidophenol, please contact the Tech Serve Solutions sales team through our website or direct contact details.
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