3-Acetamidophenylboronic acid
3-Acetamidophenylboronic acid (CAS 78887-39-5) is an organoboron compound with the linear formula CH3CONHC6H4B(OH)2 and a molecular weight of 178.98 g/mol. This aryl boronic acid derivative serves as a key reactant in various organic syntheses, notably in Suzuki-Miyaura coupling reactions and trifluoromethylation processes. It is instrumental in the development of novel pharmaceutical agents.
- IUPAC
- 3-Acetamidobenzeneboronic acid
- Synonyms
- 3-Acetamidobenzeneboronic acid
Suzuki-Miyaura Coupling Reactions
3-Acetamidophenylboronic acid is a valuable building block in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions, facilitating the formation of carbon-carbon bonds for complex molecule synthesis.
Trifluoromethylation
This compound is employed as a reactant in trifluoromethylation reactions, enabling the introduction of the trifluoromethyl group, which is a crucial moiety in many pharmaceuticals.
Synthesis of NMDA Receptor Antagonists
It is utilized in the synthesis of NR2B subtype NMDA receptor antagonists, compounds investigated for their potential antidepressant activity.
Development of Enzyme Inhibitors
The compound serves as a precursor in the synthesis of various inhibitors, including 17,20-lyase inhibitors and antimitotic/antitumor agents.
| Molecular weight | 178.98 |
|---|---|
| Linear formula | CH3CONHC6H4B(OH)2 |
| Application | Reactant involved in: • Suzuki-Miyaura coupling reactions1• Trifluoromethylation2Reactant involved in the synthesis of a variety of inhibitors including:• NR2B subtype of NMDA receptor antagonists for antidepressant activity3• Biphenylylmethylimidazole derivatives for use as 17,20-lyase inhibitors4• (Indolyl)-3,5-substituted benzene analogs with antimitotic and antitumor activity5• Substituted pyrrolidines and tetrahydrofurans as AMPA receptor positive modulators6 |
| Melting point | 135 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Acetamidophenylboronic acid used for?
+
3-Acetamidophenylboronic acid is used as a reactant in Suzuki-Miyaura coupling reactions and trifluoromethylation, and in the synthesis of various inhibitors and receptor antagonists for pharmaceutical research.
What are the CAS number and linear formula for 3-Acetamidophenylboronic acid?
+
The CAS number is 78887-39-5, and the linear formula is CH3CONHC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply for 3-Acetamidophenylboronic acid?
+
Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. As per the data, it is not represented as USP, BP, or EP grade. Please refer to the product specification sheet for detailed purity information.
How should 3-Acetamidophenylboronic acid be handled safely?
+
Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Consult the Safety Data Sheet for comprehensive safety and handling instructions.
Is 3-Acetamidophenylboronic acid shipped internationally?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3-Acetamidophenylboronic acid.
How can I request a sample or quote for 3-Acetamidophenylboronic acid?
+
To request a sample or a quotation, please contact our sales department through the website or by phone, providing the product name and CAS number.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis