3,5-Dimethoxyphenol
3,5-Dimethoxyphenol (CAS 500-99-2), a phenol derivative with the molecular formula (CH3O)2C6H3OH and a molecular weight of 154.16 g/mol, is a valuable organic building block. It is commonly employed in chemical synthesis and research. Its structure, featuring two methoxy groups and a hydroxyl group on a benzene ring, makes it a versatile intermediate for various organic transformations and the development of complex molecules.
- IUPAC
- Phloroglucinol dimethyl ether
- Synonyms
- Phloroglucinol dimethyl ether

Organic Synthesis Intermediate
3,5-Dimethoxyphenol serves as a key intermediate in the synthesis of more complex organic molecules. Its phenolic hydroxyl group and methoxy substituents allow for diverse chemical modifications and functionalisation.
Research and Development
This compound is utilised in research laboratories for developing new analytical methods and in studies involving iron porphyrin phenoxides, contributing to advancements in chemical and analytical sciences.
Alkaloid Analysis
It has been applied in the development of advanced liquid chromatography-mass spectrometry (LC-MS) techniques for the simultaneous identification and quantification of novel alkaloids and alkaloidal diterpenoids.
| Molecular weight | 154.16 |
|---|---|
| Linear formula | (CH3O)2C6H3OH |
| Assay | 99% |
| Boiling point | 172-175 °C/17 mmHg(lit.) |
| Application | 3,5-Dimethoxyphenol has been used in a study on iron porphyrin phenoxides1. It was used to develop a new analytical method using LC-MS that enables the simultaneous identification and quantification of new alkaloids and the alkaloidal diterpenoids2. |
| Melting point | 40-43 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Dimethoxyphenol used for?
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3,5-Dimethoxyphenol is primarily used as an intermediate in organic synthesis and in research and development, including studies on iron porphyrin phenoxides and the development of analytical methods for alkaloids.
What is the CAS number and chemical formula for 3,5-Dimethoxyphenol?
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The CAS number is 500-99-2 and the linear formula is (CH3O)2C6H3OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Dimethoxyphenol with a purity of 99%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and chemical synthesis purposes.
How should 3,5-Dimethoxyphenol be handled safely?
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Handle 3,5-Dimethoxyphenol with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. It is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
Is 3,5-Dimethoxyphenol exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3,5-Dimethoxyphenol.
How can I request a quote or sample for 3,5-Dimethoxyphenol?
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To request a quote or a sample of 3,5-Dimethoxyphenol, please contact our sales team through the TSS website or by calling our customer service.
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