3,5-Difluorophenylmagnesium bromide solution
3,5-Difluorophenylmagnesium bromide solution (CAS: 62351-47-7, F₂C₆H₃MgBr) is a versatile Grignard reagent supplied by Tech Serve Solutions at a 0.5 M concentration in THF. This organometallic compound serves as a key building block in organic synthesis, enabling the formation of new carbon-carbon bonds. Its utility spans the creation of complex molecules, particularly in pharmaceutical and agrochemical research and development.
- Synonyms
- F2C6H3MgBr
Carbon-Carbon Bond Formation
As a Grignard reagent, 3,5-Difluorophenylmagnesium bromide efficiently reacts with electrophiles such as aldehydes, ketones, esters, and epoxides to create new carbon-carbon bonds. This is fundamental in constructing more complex organic structures.
Synthesis of Fluorinated Aromatics
This reagent is instrumental in introducing the 3,5-difluorophenyl moiety into target molecules. Fluorinated aromatic compounds are of significant interest in medicinal chemistry and materials science due to their unique electronic and metabolic properties.
Pharmaceutical Intermediate Synthesis
It serves as a valuable intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates. The difluorophenyl group can impart desirable pharmacokinetic or pharmacodynamic characteristics.
Agrochemical Research
The compound can be employed in the development of novel agrochemicals, where fluorinated motifs often contribute to enhanced biological activity and stability.
| Molecular weight | 217.29 |
|---|---|
| Linear formula | F2C6H3MgBr |
| Boiling point | 65 °C |
| Density | 0.971 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Difluorophenylmagnesium bromide solution used for?
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3,5-Difluorophenylmagnesium bromide solution is primarily used as a Grignard reagent in organic synthesis for carbon-carbon bond formation, particularly in the creation of fluorinated aromatic compounds for pharmaceutical and agrochemical research.
What is the CAS number and formula for this product?
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The CAS number is 62351-47-7, and the linear formula is F₂C₆H₃MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Difluorophenylmagnesium bromide solution at a concentration of 0.5 M in THF. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should 3,5-Difluorophenylmagnesium bromide solution be handled?
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This is a flammable liquid and vapour (H225) and can cause serious eye irritation (H319) and respiratory irritation (H335). It is suspected of causing cancer (H351) and may form explosive peroxides. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Store refrigerated at 2-8°C.
How is 3,5-Difluorophenylmagnesium bromide solution packed and shipped?
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As a specialist global supplier, Tech Serve Solutions offers secure and compliant packaging for export, adhering to international shipping regulations for hazardous materials like UN 2924.
How can I request a quote or sample?
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To request a quote or a sample of 3,5-Difluorophenylmagnesium bromide solution, please use the contact form on our website or contact our sales department directly.
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