3,5-Difluorophenylacetic acid

CAS 105184-38-1F2C6H3CH2CO2HChemical Synthesis

3,5-Difluorophenylacetic acid (CAS: 105184-38-1) is a fluorinated organic compound with the molecular formula F ₂ C ₆ H ₃ CH ₂ CO ₂ H and a molecular weight of 172.13 g/mol. This chemical serves as a valuable building block in organic synthesis, particularly for introducing the 3,5-difluorophenylacetyl moiety into more complex molecules. It is frequently employed in the development of pharmaceutical intermediates and advanced materials, offering unique electronic and steric properties due to the presence of fluorine atoms.

Synonyms: F2C6H3CH2CO2H

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3,5-Difluorophenylacetic acid (F2C6H3CH2CO2H) — chemical structure, CAS 105184-38-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC7-C8Carbonyl CompoundsCarboxylic AcidsChemical SynthesisFluorinated Building BlocksOrganic Building Blocks

01 /Applications

Synthesis of N-acylalanine Derivatives

3,5-Difluorophenylacetic acid is utilised as a key precursor in the synthesis of various N-acylalanine derivatives, such as N-acylalanine itself, contributing to the development of novel peptides and peptidomimetics.

Intermediate for Complex Organic Molecules

This compound is instrumental in the synthesis of more elaborate organic structures, including peptide fragments like N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-L-phenylglycine tert-butyl ester, where it provides a specific difluorinated phenylacetic acid fragment.

Research and Development in Medicinal Chemistry

Its fluorinated nature makes 3,5-Difluorophenylacetic acid a useful scaffold in medicinal chemistry research for exploring structure-activity relationships and designing new drug candidates.

02 /Properties

Molecular weight	172.13
Linear formula	F2C6H3CH2CO2H
Assay	99%
Application	3,5-Difluorophenylacetic acid has been used in the synthesis of:• N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-L-phenylglycine tert-butyl ester1• N-acylalanine2
Melting point	68-70 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

105184-38-1

MDL number

MFCD00010316

PubChem substance

24857468

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3,5-Difluorophenylacetic acid used for?

3,5-Difluorophenylacetic acid is primarily used as a building block in organic synthesis, particularly for preparing N-acylalanine derivatives and other complex organic molecules in research and development, including medicinal chemistry.

What is the CAS number and molecular formula for 3,5-Difluorophenylacetic acid?

The CAS number is 105184-38-1 and the molecular formula is F ₂ C ₆ H ₃ CH ₂ CO ₂ H.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 3,5-Difluorophenylacetic acid with a purity of 99%. TSS does not represent this product as USP, BP, or EP grade.

How should 3,5-Difluorophenylacetic acid be handled safely?

As indicated by its GHS classification (Warning, H315-H319-H335), 3,5-Difluorophenylacetic acid can cause skin irritation, serious eye irritation, and respiratory irritation. Appropriate personal protective equipment including eyeshields, gloves, and a dust mask (type N95 US) should be worn, and handling should occur in a well-ventilated area. In case of eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do.

Is 3,5-Difluorophenylacetic acid shipped internationally?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3,5-Difluorophenylacetic acid.

How can I request a sample or quote for 3,5-Difluorophenylacetic acid?

To request a sample or a quote for 3,5-Difluorophenylacetic acid, please contact our sales team through the TSS website or your designated sales representative.