3,5-Difluorophenyl isocyanate
3,5-Difluorophenyl isocyanate (CAS: 83594-83-6), with the molecular formula F₂C₆H₃NCO and a molecular weight of 155.10 g/mol, is a key organic building block. This fluorinated isocyanate is primarily employed in chemical synthesis for the introduction of the 3,5-difluorophenyl moiety into larger molecules. Its reactivity makes it valuable in the development of pharmaceuticals, agrochemicals, and advanced materials.
- Synonyms
- F2C6H3NCO
Pharmaceutical Intermediate
3,5-Difluorophenyl isocyanate serves as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs). It allows for the incorporation of the difluorophenyl group, which can modulate drug properties such as metabolic stability and binding affinity.
Agrochemical Synthesis
This compound is utilised in the creation of novel agrochemicals. The presence of fluorine atoms can enhance the efficacy and environmental profile of pesticides and herbicides by influencing their biological activity and persistence.
Materials Science
As a building block, 3,5-Difluorophenyl isocyanate can be incorporated into polymers and other advanced materials. Its inclusion can impart specific thermal, electronic, or surface properties due to the unique characteristics of the fluorinated aromatic ring.
Research and Development
Researchers utilise 3,5-Difluorophenyl isocyanate in exploratory synthesis and methodology development. Its defined structure and reactive functional group make it a useful reagent for creating diverse chemical entities.
| Molecular weight | 155.10 |
|---|---|
| Linear formula | F2C6H3NCO |
| Assay | 97% |
| Boiling point | 159 °C(lit.) |
| Density | 1.31 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.493(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 54 °C / 129.2 °F |
| Transport (UN / ADR) | UN 3080 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37/38 |
| Safety statements (S) | 16-26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Difluorophenyl isocyanate used for?
+
3,5-Difluorophenyl isocyanate is primarily used as a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. It is also employed in research and development for creating new chemical entities.
What is the CAS number and formula for 3,5-Difluorophenyl isocyanate?
+
The CAS number for 3,5-Difluorophenyl isocyanate is 83594-83-6, and its linear formula is F₂C₆H₃NCO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3,5-Difluorophenyl isocyanate with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3,5-Difluorophenyl isocyanate be handled?
+
3,5-Difluorophenyl isocyanate is a flammable liquid and vapour (H226) and is harmful if swallowed, in contact with skin, or if inhaled (H302, H312, H332). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) and an allergic skin reaction (H317) or allergy or asthma symptoms or breathing difficulties if inhaled (H334). Always use appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, and handle in a well-ventilated area.
Is 3,5-Difluorophenyl isocyanate shipped internationally?
+
Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including 3,5-Difluorophenyl isocyanate.
How can I request a quote or sample?
+
To request a quote or a sample of 3,5-Difluorophenyl isocyanate, please contact our sales team via the website or direct inquiry.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis