3,4-Dehydro-DL-proline
3,4-Dehydro-DL-proline (CAS: 3395-35-5), also known as (±)-3-Pyrroline-2-carboxylic acid, is a heterocyclic organic compound with the molecular formula C5H7NO2 and a molecular weight of 113.11 g/mol. It serves as a valuable building block in organic synthesis and peptide chemistry. This compound is primarily utilised in chemical biology research and the development of novel molecular structures.
- IUPAC
- (±)-2,5-Dihydro-1H-pyrrole-2-carboxylic acid,(±)-3-Pyrroline-2-carboxylic acid
- Synonyms
- (±)-2,5-Dihydro-1H-pyrrole-2-carboxylic acid(±)-3-Pyrroline-2-carboxylic acid

Chemical Synthesis
3,4-Dehydro-DL-proline is employed as a versatile intermediate in the synthesis of complex organic molecules. Its unique structural features allow for various chemical transformations and the construction of novel carbon skeletons.
Peptide Chemistry
This unnatural amino acid derivative is incorporated into peptides to modify their structure and properties. It can influence peptide conformation, stability, and biological activity, aiding in the design of peptidomimetics.
Chemical Biology
Researchers utilise 3,4-Dehydro-DL-proline to study biological processes and develop new probes. Its inclusion in biomolecules can help elucidate mechanisms of action or create novel bioactive compounds.
Proline Derivative Research
As a proline derivative, it is instrumental in exploring structure-activity relationships and developing analogues with altered functionalities for various research applications.
| Molecular weight | 113.11 |
|---|---|
| Empirical formula | C5H7NO2 |
| Assay | 98% |
| Melting point | 245 °C (dec.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Dehydro-DL-proline used for?
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3,4-Dehydro-DL-proline (CAS: 3395-35-5) is used in chemical synthesis, peptide chemistry, chemical biology, and as a proline derivative in research.
What is the CAS number and formula for 3,4-Dehydro-DL-proline?
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The CAS number is 3395-35-5 and the empirical formula is C5H7NO2.
What grade and purity does Tech Serve Solutions supply for 3,4-Dehydro-DL-proline?
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Tech Serve Solutions supplies 3,4-Dehydro-DL-proline with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations for 3,4-Dehydro-DL-proline?
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This compound is classified with WGK Germany 3. Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, should be used when handling. It decomposes upon heating above 245 °C.
How is 3,4-Dehydro-DL-proline packed and shipped?
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Tech Serve Solutions reliably packs and ships fine chemicals, pharmaceutical intermediates, and laboratory reagents globally, ensuring product integrity during transit.
How can I request a sample or quote for 3,4-Dehydro-DL-proline?
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To request a sample or obtain a quotation for 3,4-Dehydro-DL-proline, please contact our sales team through the website or by phone.
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