3,4,5-Trimethoxybenzyl chloride
3,4,5-Trimethoxybenzyl chloride (CAS 3840-30-0) is an organic compound with the molecular formula C10H13ClO3 and a molecular weight of 216.66 g/mol. This halogenated aromatic compound serves as a valuable building block in organic synthesis. It is primarily utilised in chemical synthesis for the preparation of more complex molecules, particularly within the pharmaceutical and fine chemical industries. Stored at 2-8°C, it is soluble in methanol.
- IUPAC
- 5-(Chloromethyl)pyrogallol trimethyl ether
- Synonyms
- 3840-30-0C10H13ClO35-(Chloromethyl)pyrogallol trimethyl ether

Organic Synthesis Intermediate
3,4,5-Trimethoxybenzyl chloride is employed as a reactive intermediate in multi-step organic synthesis pathways. Its benzyl chloride moiety allows for facile nucleophilic substitution reactions, enabling the introduction of the 3,4,5-trimethoxybenzyl group into various molecular structures.
Pharmaceutical Research
This compound acts as a key building block in the research and development of new pharmaceutical agents. The 3,4,5-trimethoxyphenyl structure is present in several biologically active molecules, making this chloride derivative a useful precursor for medicinal chemistry exploration.
Fine Chemical Manufacturing
It is used in the production of specialized fine chemicals. The specific arrangement of methoxy groups on the benzyl ring can impart unique properties to the target molecules, finding applications in diverse chemical sectors.
| Molecular weight | 216.66 |
|---|---|
| Empirical formula | C10H13ClO3 |
| Assay | ≥98.0% (AT) |
| Solubility | methanol: soluble0.1 g/mL, clear |
| Storage temperature | 2-8°C |
| Melting point | 60-63 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4,5-Trimethoxybenzyl chloride used for?
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3,4,5-Trimethoxybenzyl chloride is primarily used as an intermediate in organic synthesis and for the preparation of more complex molecules, including potential pharmaceutical agents and fine chemicals.
What is the CAS number and formula for 3,4,5-Trimethoxybenzyl chloride?
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The CAS number is 3840-30-0, and the molecular formula is C10H13ClO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4,5-Trimethoxybenzyl chloride with an assay of ≥98.0% (AT). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3,4,5-Trimethoxybenzyl chloride be handled?
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3,4,5-Trimethoxybenzyl chloride is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including eyeshields, faceshields, suitable gloves, and a respirator, must be used. Handle only in a well-ventilated area.
How is 3,4,5-Trimethoxybenzyl chloride packed and shipped?
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This chemical is shipped according to UN 3261 regulations for corrosive solid organic substances, acidic, n.o.s. (3,4,5-Trimethoxybenzyl chloride), hazard class 8, packing group II. Specific packaging details for export are available upon request.
How can I request a sample or quote for 3,4,5-Trimethoxybenzyl chloride?
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To request a sample or obtain a quotation for 3,4,5-Trimethoxybenzyl chloride, please contact our sales team via the website or email, referencing the product name and CAS number (3840-30-0).
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