2-(Trifluoromethyl)phenylboronic acid
2-(Trifluoromethyl)phenylboronic acid (CAS: 1423-27-4), with the formula CF3C6H4B(OH)2 and a molecular weight of 189.93, is a specialised aryl boronic acid derivative. It is primarily employed as a key building block and intermediate in organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling. Its trifluoromethyl group imparts unique electronic properties, making it valuable in the development of pharmaceuticals and advanced materials.
Suzuki-Miyaura Cross-Coupling Reactions
This boronic acid is a versatile reagent for Suzuki-Miyaura cross-coupling reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of complex biaryl compounds and substituted aromatic systems.
Pharmaceutical Intermediate
Utilised in the multi-step synthesis of active pharmaceutical ingredients (APIs). The trifluoromethyl moiety is often incorporated into drug candidates to modulate lipophilicity, metabolic stability, and binding affinity.
Materials Science
Serves as a building block for functional organic materials, including polymers and liquid crystals, where the electronic properties conferred by the trifluoromethylphenyl group are beneficial.
Agrochemical Synthesis
Employed in the development of novel agrochemicals, leveraging its structural features for designing compounds with specific biological activities.
| Molecular weight | 189.93 |
|---|---|
| Linear formula | CF3C6H4B(OH)2 |
| Assay | ≥95.0% |
| Melting point | 111-114 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoromethyl)phenylboronic acid primarily used for?
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2-(Trifluoromethyl)phenylboronic acid is primarily used as a building block and intermediate in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, and in the development of pharmaceuticals, agrochemicals, and materials.
What is the CAS number and chemical formula for 2-(Trifluoromethyl)phenylboronic acid?
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The CAS number is 1423-27-4 and the chemical formula is CF3C6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Trifluoromethyl)phenylboronic acid with an assay of ≥95.0%. This product is not classified as USP, BP, or EP grade and is intended for research and chemical synthesis purposes.
How should 2-(Trifluoromethyl)phenylboronic acid be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended if dust or aerosols are generated. Consult the Safety Data Sheet (SDS) for comprehensive handling and hazard information.
Does Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-(Trifluoromethyl)phenylboronic acid, adhering to all necessary export regulations.
How can I request a quote or sample?
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To request a quote or a sample of 2-(Trifluoromethyl)phenylboronic acid, please contact our sales team via the website or direct email, providing your specific requirements.
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