2-Fluorophenylacetic acid
2-Fluorophenylacetic acid (CAS: 451-82-1; Formula: FC6H4CH2CO2H; Molar Mass: 154.14 g/mol) is a valuable organic building block. This fluorinated carboxylic acid serves as a key intermediate in the synthesis of complex organic molecules, particularly in pharmaceutical research and development. Its structure, featuring both a phenyl ring with a fluorine substituent and a carboxylic acid group, allows for diverse chemical transformations. Supplied by Tech Serve Solutions, it is offered at a 98% purity.
Synthesis of Heterocyclic Compounds
2-Fluorophenylacetic acid has been utilised in the synthesis of fused heterocyclic systems, such as thiazolino[3,2-c]pyrimidin-5,7-diones, demonstrating its utility in constructing complex ring structures relevant to medicinal chemistry.
Preparation of Diamine Intermediates
This compound is employed in the preparation of specific diamine derivatives, for instance, N-[2-(3,4-dichlorophenyl)-ethyl]-N′-[2-(2-fluorophenyl)-ethyl]-ethane-1,2-diamine, highlighting its role in creating tailored molecular architectures for further chemical study.
Chiral Analysis
As a chiral derivatizing agent, 2-Fluorophenylacetic acid can be used for the determination of enantiomeric composition in chiral compounds via 19F NMR spectroscopy, aiding in the characterisation of stereoisomers.
| Molecular weight | 154.14 |
|---|---|
| Linear formula | FC6H4CH2CO2H |
| Assay | 98% |
| Application | 2-Fluorophenylacetic acid was used: • in the synthesis of thiazolino[3,2-c]pyrimidin-5,7-diones1 and N-[2-(3,4-dichlorophenyl)-ethyl]-N′-[2-(2-fluorophenyl)-ethyl]-ethane-1,2-diamine2• as chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by 19F NMR spectroscopy3 |
| Melting point | 60-62 °C(lit.) |
Hazard statements
- H315Causes skin irritation
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 38 |
| Safety statements (S) | 22-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluorophenylacetic acid used for?
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2-Fluorophenylacetic acid is primarily used as a building block in organic synthesis, including the preparation of heterocyclic compounds, diamine intermediates, and in chiral analysis.
What is the CAS number and molecular formula for 2-Fluorophenylacetic acid?
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The CAS number is 451-82-1 and the molecular formula is FC6H4CH2CO2H.
What grade and purity does Tech Serve Solutions supply for 2-Fluorophenylacetic acid?
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Tech Serve Solutions supplies 2-Fluorophenylacetic acid with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2-Fluorophenylacetic acid be handled safely?
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2-Fluorophenylacetic acid is classified as an irritant (H315). When handling, it is advised to wear eye shields, gloves, and a dust mask (type N95 or equivalent). Avoid breathing dust and ensure adequate ventilation.
Is 2-Fluorophenylacetic acid exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals like 2-Fluorophenylacetic acid.
How can I request a quote or sample for 2-Fluorophenylacetic acid?
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To request a quote or sample, please contact our sales team through the website or provide your details via the 'enquire' button on the product page.
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