2-Fluorophenyl isothiocyanate
2-Fluorophenyl isothiocyanate (CAS 38985-64-7), with the molecular formula FC 6 H 4 NCS and a molar mass of 153.18 g/mol, is a fluorinated organic building block. It is primarily utilised in chemical synthesis, particularly in the preparation of various organic compounds. This compound offers a reactive isothiocyanate functional group alongside a fluorinated phenyl ring, making it a versatile intermediate for creating more complex molecules in research and development settings.
Synthesis of Acylthiosemicarbazides
2-Fluorophenyl isothiocyanate serves as a key reagent in the synthesis of acylthiosemicarbazides. This application is crucial for developing new chemical entities with potential biological activities.
Fluorinated Organic Synthesis
As a fluorinated building block, this compound is valuable for introducing fluorine atoms into organic molecules. Fluorine substitution can significantly alter the physical, chemical, and biological properties of compounds, a common strategy in medicinal chemistry.
Intermediate for Heterocyclic Compounds
The isothiocyanate moiety readily reacts with nucleophiles, enabling its use in the construction of various heterocyclic ring systems, which are prevalent in pharmaceuticals and agrochemicals.
| Molecular weight | 153.18 |
|---|---|
| Linear formula | FC6H4NCS |
| Assay | 98% |
| Density | 1.248 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.6254(lit.) |
| Application | 2-Fluorophenyl isothiocyanate has been used in the synthesis of acylthiosemicarbazides1. |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 97 °C / 206.6 °F |
| Transport (UN / ADR) | UN 1760 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluorophenyl isothiocyanate used for?
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2-Fluorophenyl isothiocyanate is used as a chemical intermediate in organic synthesis, notably in the preparation of acylthiosemicarbazides and other fluorinated organic compounds.
What are the CAS number and molecular formula for 2-Fluorophenyl isothiocyanate?
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The CAS number is 38985-64-7 and the molecular formula is FC 6 H 4 NCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluorophenyl isothiocyanate with a minimum purity of 98%. This product is typically intended for research and chemical synthesis applications, and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 2-Fluorophenyl isothiocyanate be handled safely?
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2-Fluorophenyl isothiocyanate is classified as corrosive and can cause severe skin burns and eye damage, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including gloves, eye protection (goggles and face shield), and respiratory protection (type ABEK respirator filter). Work in a well-ventilated area or fume hood.
How is 2-Fluorophenyl isothiocyanate packed and shipped?
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2-Fluorophenyl isothiocyanate is shipped as a hazardous material, UN 1760, Class 8, Packing Group II. Packaging adheres to international regulations for safe transport.
How can I request a quote or sample for 2-Fluorophenyl isothiocyanate?
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To request a quote or sample, please contact our sales department via the website or by calling us directly. Provide the product name and CAS number for prompt service.
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