2-Fluorobenzyl bromide
2-Fluorobenzyl bromide (CAS: 446-48-0; Formula: C7H6BrF; MW: 189.02) is a halogenated organic compound. It serves as a key building block in organic synthesis, particularly for the introduction of the 2-fluorobenzyl group into molecules. Its reactivity makes it valuable in the preparation of pharmaceuticals and other complex organic structures. Tech Serve Solutions supplies this reagent with an assay of 98%.
- IUPAC
- α-Bromo-2-fluorotoluene
- Synonyms
- α-Bromo-2-fluorotoluene
Synthesis of Heterocyclic Compounds
2-Fluorobenzyl bromide is utilized in the synthesis of various heterocyclic systems, such as 2-pyrrolo[2,3-d]pyrimidines. This application highlights its role in constructing complex nitrogen-containing ring structures common in medicinal chemistry.
Alkylation Agent in Organic Synthesis
This compound acts as an effective alkylating agent. For instance, it has been employed in the synthesis of 8-alkylated imidazolo[1,2-a]pyrimid-5-ones, demonstrating its utility in modifying existing ring systems.
Pharmaceutical Intermediate
2-Fluorobenzyl bromide is an intermediate in the synthesis of active pharmaceutical ingredients. Notably, it has been used in the synthetic pathway for the antiplatelet drug prasugrel.
| Molecular weight | 189.02 |
|---|---|
| Linear formula | FC6H4CH2Br |
| Assay | 98% |
| Boiling point | 84-85 °C/15 mmHg(lit.) |
| Density | 1.567 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.552(lit.) |
| Application | 2-Fluorobenzyl bromide was used:• in the synthesis of 2-pyrrolo[2,3-d]pyrimidines1• as alkylating agent during the synthesis of 8-alkylated imidazolo[1,2-a]pyrimid-5-ones2• in the synthesis of prasugrel |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 83 °C / 181.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluorobenzyl bromide used for?
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2-Fluorobenzyl bromide is used as a building block in organic synthesis, particularly for the preparation of pharmaceuticals and complex organic structures. It has been employed in the synthesis of 2-pyrrolo[2,3-d]pyrimidines, 8-alkylated imidazolo[1,2-a]pyrimid-5-ones, and prasugrel.
What is the CAS number and molecular formula for 2-Fluorobenzyl bromide?
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The CAS number for 2-Fluorobenzyl bromide is 446-48-0, and its molecular formula is FC6H4CH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluorobenzyl bromide with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Fluorobenzyl bromide be handled safely?
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2-Fluorobenzyl bromide is classified as Danger, causing severe skin burns and eye damage, and may cause respiratory irritation (H314-H335). Appropriate personal protective equipment, including faceshields, gloves, goggles, and suitable respiratory protection (e.g., type ABEK respirator filter), is essential. Handle in a well-ventilated area.
Is 2-Fluorobenzyl bromide typically exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Fluorobenzyl bromide.
How can I request a quote or sample of 2-Fluorobenzyl bromide?
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To request a quote or sample of 2-Fluorobenzyl bromide, please contact our sales team via the website or phone.
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