2-Fluoro-5-(trifluoromethyl)phenylboronic acid
2-Fluoro-5-(trifluoromethyl)phenylboronic acid (CAS 352535-96-7) is an organoboron compound with the formula FC6H3(CF3)B(OH)2 and a molecular weight of 207.92 g/mol. It serves as a valuable intermediate in organic synthesis. This aryl boronic acid is utilised in various coupling reactions and as a reactant for functionalisation, conjugate addition, and in the preparation of potential antitumor agents.
- IUPAC
- 2-fluoro-5-(trifluoromethyl)benzeneboronic acid
Functionalisation Reactions
This compound acts as a reactant for functionalisation via lithiation followed by reaction with electrophiles, enabling the synthesis of complex organic molecules.
Catalytic Conjugate Addition
It is employed in selective rhodium-catalyzed conjugate addition reactions, offering a pathway to stereoselective synthesis of valuable compounds.
Antitumor Agent Precursors
2-Fluoro-5-(trifluoromethyl)phenylboronic acid is used in the preparation of inhibitors of kinesin spindle protein (KSP), which are investigated for their potential as antitumor agents.
| Molecular weight | 207.92 |
|---|---|
| Linear formula | FC6H3(CF3)B(OH)2 |
| Application | Reactant for:• Functionalization via lithiation and reaction with electrophiles1• Selective rhodium-catalyzed conjugate addition reactions2• Preparation of inhibitors of kinesin spindle protein (KSP) for potential use as antitumor agents3 |
| Melting point | 104-109 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-5-(trifluoromethyl)phenylboronic acid used for?
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2-Fluoro-5-(trifluoromethyl)phenylboronic acid is used as a reactant for functionalisation via lithiation and reaction with electrophiles, in selective rhodium-catalyzed conjugate addition reactions, and in the preparation of inhibitors of kinesin spindle protein (KSP) for potential use as antitumor agents.
What is the CAS number and formula for 2-Fluoro-5-(trifluoromethyl)phenylboronic acid?
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The CAS number is 352535-96-7 and the linear formula is FC6H3(CF3)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical typically as a research or technical grade. We do not represent it as USP, BP, or EP grade unless explicitly stated otherwise in the product specifications.
What are the safety and handling precautions for this compound?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified under WGK Germany 3, indicating a high hazard to water.
How is 2-Fluoro-5-(trifluoromethyl)phenylboronic acid shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents. We adhere to all regulations for the safe packing and international export of our products.
How can I request a sample or quote for 2-Fluoro-5-(trifluoromethyl)phenylboronic acid?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (352535-96-7).
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