2-Fluoro-5-(trifluoromethyl)pyridine
2-Fluoro-5-(trifluoromethyl)pyridine (CAS 69045-82-5) is a fluorinated heterocyclic compound with the molecular formula C6H3F4N and a molecular weight of 165.09 g/mol. This chemical serves as a valuable building block in organic synthesis. Its unique structure, incorporating both a fluorine atom and a trifluoromethyl group on a pyridine ring, makes it useful in the development of novel molecules for various advanced chemical applications.

Fluorinated Building Block
Utilised in the synthesis of complex organic molecules where the introduction of a fluorinated pyridine moiety is desired. Its specific substitution pattern allows for regioselective reactions in multi-step synthetic pathways.
Pharmaceutical Intermediate
Serves as a key intermediate in the research and development of new pharmaceutical agents. The incorporation of fluorine and trifluoromethyl groups can modulate pharmacokinetic properties such as metabolic stability and lipophilicity.
Agrochemical Development
Employed in the design and synthesis of novel agrochemicals, including pesticides and herbicides. The trifluoromethylpyridine scaffold can impart desirable biological activity and environmental persistence profiles.
Material Science Research
Investigated for its potential use in the development of advanced materials. The electronic properties conferred by the fluorine substituents may find applications in specialty polymers or electronic components.
| Molecular weight | 165.09 |
|---|---|
| Empirical formula | C6H3F4N |
| Assay | 97% |
| Density | 1.368 g/mL at 25 °C |
| Refractive index | n20/D 1.401 |


Hazard statements
- H226Flammable liquid and vapour
- H317May cause an allergic skin reaction
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
| Flash point | 32 °C / 89.6 °F |
|---|---|
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-43-52/53 |
| Safety statements (S) | 24-37-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-5-(trifluoromethyl)pyridine used for?
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2-Fluoro-5-(trifluoromethyl)pyridine is primarily used as a building block in organic synthesis, particularly for creating fluorinated organic compounds. It finds applications in the development of pharmaceuticals, agrochemicals, and potentially advanced materials.
What are the CAS number and formula for 2-Fluoro-5-(trifluoromethyl)pyridine?
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The CAS number for 2-Fluoro-5-(trifluoromethyl)pyridine is 69045-82-5, and its molecular formula is C6H3F4N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluoro-5-(trifluoromethyl)pyridine with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
What are the main safety hazards associated with this chemical?
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2-Fluoro-5-(trifluoromethyl)pyridine is a flammable liquid and vapour (H226) that may cause an allergic skin reaction (H317) and is harmful to aquatic life with long lasting effects (H412). Handle with appropriate personal protective equipment in a well-ventilated area.
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Fluoro-5-(trifluoromethyl)pyridine, adhering to all necessary shipping and customs regulations.
How can I request a sample or quote?
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To request a sample or a quote for 2-Fluoro-5-(trifluoromethyl)pyridine, please contact our sales team via the website or direct email, providing your specific requirements.
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