2-Fluoro-4-(trifluoromethyl)pyridine

CAS 118078-66-3C6H3F4NChemical Synthesis

2-Fluoro-4-(trifluoromethyl)pyridine (CAS 118078-66-3) is a fluorinated pyridine building block. Its chemical formula is C6H3F4N. This compound is primarily utilised as a reactant in the synthesis of aminopyridines through amination reactions. It also serves as a catalytic ligand in palladium-catalyzed aerobic oxidative coupling reactions for the regioselective preparation of tetramethylbiphenyls. With an assay of ≥94%, it is suitable for research and chemical synthesis applications.

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2-Fluoro-4-(trifluoromethyl)pyridine (C6H3F4N) — chemical structure, CAS 118078-66-3; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Reactant for Aminopyridine Synthesis

Used as a key intermediate in the preparation of various aminopyridines via amination reactions, facilitating the introduction of the fluorinated pyridine moiety into complex molecules.

Catalytic Ligand in Coupling Reactions

Functions as a ligand in palladium-catalyzed aerobic oxidative coupling reactions. It aids in the regioselective synthesis of tetramethylbiphenyls from xylenes.

02 /Properties

Molecular weight	165.09
Empirical formula	C6H3F4N
Assay	≥94%
Density	1.355 g/mL at 25 °C
Refractive index	n20/D 1.400
Application	Reactant for:• Preparation of aminopyridines via amination reactions1Catalytic ligand for:• Regioselective preparation of tetramethylbiphenyls via aerobic oxidative coupling of xylene catalyzed by palladium2

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H226Flammable liquid and vapour
H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P301IF SWALLOWED
P305IF IN EYES

Flash point	23 °C / 73.4 °F
Transport (UN / ADR)	UN 1992 3/PG 3
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	10-25-36/37/38
Safety statements (S)	26-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

118078-66-3

MDL number

MFCD09879262

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-Fluoro-4-(trifluoromethyl)pyridine used for?

It is primarily used as a reactant for the preparation of aminopyridines and as a catalytic ligand for the synthesis of tetramethylbiphenyls.

What is the CAS number and chemical formula?

The CAS number is 118078-66-3 and the chemical formula is C6H3F4N.

What is the purity or grade of this chemical?

This chemical has an assay of ≥94%. It is supplied for research and chemical synthesis purposes.

What are the main hazards associated with this chemical?

This chemical is flammable and harmful if swallowed. It can cause skin irritation, serious eye irritation, and respiratory irritation. It requires careful handling according to safety data sheets.