2-Fluoro-4-methylphenylboronic acid
2-Fluoro-4-methylphenylboronic acid (CAS: 170981-26-7) is an organoboron compound with the formula FC6H3(CH3)B(OH)2 and a molecular weight of 153.95 g/mol. This disubstituted aryl boronic acid serves as a key reactant in palladium-catalyzed Suzuki-Miyaura coupling reactions. Its utility in facilitating carbon-carbon bond formation makes it a valuable intermediate in various organic synthesis pathways, particularly within pharmaceutical and materials science research.
- IUPAC
- 4-Methyl-2-fluorophenylboronic acid
- Synonyms
- 4-Methyl-2-fluorophenylboronic acid
Suzuki-Miyaura Coupling Reactions
2-Fluoro-4-methylphenylboronic acid is an effective reactant in palladium-catalyzed Suzuki-Miyaura coupling. This reaction is widely employed for the formation of carbon-carbon bonds, enabling the synthesis of complex organic molecules.
Organic Synthesis Intermediate
As a versatile building block, this aryl boronic acid is instrumental in diverse organic synthesis strategies. It facilitates the introduction of the 2-fluoro-4-methylphenyl moiety into target compounds.
Pharmaceutical Research
The compound finds application in the development of novel pharmaceutical agents. Its structure can be incorporated into lead compounds undergoing medicinal chemistry optimisation.
| Molecular weight | 153.95 |
|---|---|
| Linear formula | FC6H3(CH3)B(OH)2 |
| Application | Reactant for:• Water-accelerated Pd-Catalyzed Suzuki-Miyaura coupling1 |
| Melting point | 228-233 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-4-methylphenylboronic acid used for?
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2-Fluoro-4-methylphenylboronic acid is primarily used as a reactant in palladium-catalyzed Suzuki-Miyaura coupling reactions for organic synthesis.
What are the CAS number and formula for 2-Fluoro-4-methylphenylboronic acid?
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The CAS number is 170981-26-7 and the linear formula is FC6H3(CH3)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. The specific grade and purity available may vary; please consult the product specifications for current details. This product is not intended for USP, BP, EP, or other pharmacopoeia compliance unless explicitly stated.
How should 2-Fluoro-4-methylphenylboronic acid be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store in a well-ventilated area.
Is 2-Fluoro-4-methylphenylboronic acid a controlled substance?
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Based on the provided data, there is no indication that 2-Fluoro-4-methylphenylboronic acid is a controlled substance.
How is 2-Fluoro-4-methylphenylboronic acid packed and shipped?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals. Packaging is designed to ensure safe transit, adhering to international shipping regulations. Please contact us for specific export details.
How can I request a sample or quote for 2-Fluoro-4-methylphenylboronic acid?
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You can request a sample or obtain a quote by contacting our sales department through the methods provided on the Tech Serve Solutions website.
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