2-Fluoro-4-methylaniline
2-Fluoro-4-methylaniline (CAS: 452-80-2), with the molecular formula FC6H3(CH3)NH2 and a molecular weight of 125.14 g/mol, is a fluorinated aromatic amine. This compound serves as a valuable building block in organic synthesis. Its unique structure, featuring both a fluorine atom and an amine group on a methylated benzene ring, makes it useful in the development of various complex molecules for research and industrial applications, particularly in the pharmaceutical and agrochemical sectors.
- IUPAC
- 2-Fluoro-p-toluidine
Pharmaceutical Intermediate
2-Fluoro-4-methylaniline is utilised as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). The presence of the fluorine atom can influence the pharmacokinetic properties of drug candidates.
Agrochemical Synthesis
This compound finds application in the development of novel agrochemicals. It can be incorporated into molecules designed as pesticides, herbicides, or fungicides.
Organic Synthesis Building Block
As a versatile building block, it is employed in the construction of more complex organic molecules. The amine functionality allows for further derivatisation and coupling reactions.
Materials Science Research
The unique electronic properties conferred by the fluorine substituent may lead to its use in the research and development of advanced materials.
| Molecular weight | 125.14 |
|---|---|
| Linear formula | FC6H3(CH3)NH2 |
| Assay | 99% |
| Boiling point | 70-71 °C/7 mmHg(lit.) |
| Density | 1.108 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.533(lit.) |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 79 °C / 174.2 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-36/37/38 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-4-methylaniline used for?
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2-Fluoro-4-methylaniline is primarily used as an intermediate and building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals.
What are the CAS number and chemical formula for 2-Fluoro-4-methylaniline?
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The CAS number for 2-Fluoro-4-methylaniline is 452-80-2, and its chemical formula is FC6H3(CH3)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluoro-4-methylaniline with an assay of 99%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Fluoro-4-methylaniline be handled safely?
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2-Fluoro-4-methylaniline is a Danger substance that is toxic if swallowed, in contact with skin, and if inhaled, and causes skin and serious eye irritation. Handle with appropriate personal protective equipment including eyeshields, face shields, gloves, and suitable respiratory protection (e.g., full-face respirator, ABEK type filter).
How is 2-Fluoro-4-methylaniline packed, shipped, and exported?
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2-Fluoro-4-methylaniline is typically packed in accordance with UN 2810 (Class 6.1, PGIII) regulations for safe transport. TSS exports globally, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for 2-Fluoro-4-methylaniline?
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To request a sample or a quote for 2-Fluoro-4-methylaniline, please contact our sales team through the website or direct email, providing your contact details and required quantity.
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