N-(2-Bromo-5-methoxypyridin-3-yl)pivalamide
N-(2-Bromo-5-methoxypyridin-3-yl)pivalamide (CAS 1171920-11-8; molecular formula C11H15BrN2O2; molar mass 287.15 g/mol) is a halogenated pyridine building block used in organic and medicinal-chemistry synthesis. It is a trisubstituted 3-aminopyridine in which the amine is protected as a pivalamide, with a bromine handle at the 2-position and a methoxy group at the 5-position. These features make it a versatile intermediate for metal-catalysed cross-coupling and further functionalisation toward more complex heterocyclic targets.
- Synonyms
- N-(2-Bromo-5-methoxypyridin-3-yl)pivalamideN-(2-bromo-5-methoxypyridin-3-yl)-2,2-dimethylpropanamide2,2-dimethyl-N-(2-bromo-5-methoxypyridin-3-yl)propanamideCAS 1171920-11-8
Cross-coupling building block
The 2-bromo substituent provides a reactive handle for palladium-catalysed cross-coupling reactions such as Suzuki-Miyaura, Negishi and Stille couplings, enabling carbon-carbon bond formation on the pyridine ring.
Buchwald-Hartwig amination substrate
The aryl bromide can also undergo palladium- or copper-catalysed carbon-nitrogen coupling, allowing introduction of amine functionality to construct more elaborate aminopyridine scaffolds.
Protected aminopyridine intermediate
The pivaloyl (trimethylacetyl) group masks the 3-amino position and can act as a directing group during metalation; it is removable under hydrolytic conditions to reveal the free amine for downstream chemistry.
Pharmaceutical and agrochemical research
Functionalised methoxypyridine cores of this type are common motifs in drug discovery and agrochemical research programmes, where this compound serves as a precursor for the assembly of candidate molecules.
Laboratory reagent for heterocyclic synthesis
As a defined small-molecule building block, it is used on research and process-development scale to introduce a substituted pyridine fragment into target structures.
| Molecular weight | 287.15 |
|---|---|
| Empirical formula | C11H15BrN2O2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Bromo-5-methoxypyridin-3-yl)pivalamide used for?
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It is used as a halogenated pyridine building block in organic and medicinal-chemistry synthesis. The 2-bromo group supports palladium-catalysed cross-coupling and amination reactions, while the pivalamide protects and can direct functionalisation at the 3-amino position, making it a useful intermediate toward more complex heterocyclic and pharmaceutical targets.
What is the CAS number and molecular formula of N-(2-Bromo-5-methoxypyridin-3-yl)pivalamide?
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Its CAS number is 1171920-11-8 and its molecular formula is C11H15BrN2O2, corresponding to a molar mass of 287.15 g/mol. It belongs to the halogenated heterocyclic building blocks (pyridines) category.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/technical-grade building block for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeia grade. The specific assay and batch analysis are confirmed on the certificate of analysis (CoA) for each lot; please request the current CoA when enquiring.
How should N-(2-Bromo-5-methoxypyridin-3-yl)pivalamide be handled and stored?
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A full GHS hazard classification was not provided with this listing, so it should be treated as a research chemical not intended for medicinal, household or food use. Handle only with appropriate laboratory controls, gloves and eye protection, avoid dust formation and contact, and store cool, dry and tightly closed away from incompatible materials. Always consult the current Safety Data Sheet (SDS), which we provide on request, before use.
How is N-(2-Bromo-5-methoxypyridin-3-yl)pivalamide packed, shipped and exported?
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It is supplied in clean, sealed laboratory and bulk containers sized to the order quantity, with appropriate labelling and documentation. Tech Serve Solutions exports worldwide, arranging packaging and transport in line with applicable regulations and supplying the CoA and SDS with each consignment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and we will provide a quotation along with the CoA and SDS. Samples can be arranged for evaluation, subject to availability and applicable shipping requirements.
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