2-(Di-tert-butylphosphino)-1-phenylindole
2-(Di-tert-butylphosphino)-1-phenylindole (CAS: 740815-37-6), with molecular formula C22H28NP and a molecular weight of 337.44 g/mol, is a specialised organophosphorus compound. It functions as a highly effective ligand in various catalytic cross-coupling reactions, particularly those involving palladium catalysis. This compound is valued for its utility in complex organic synthesis and is supplied by TSS for research and industrial applications.
- IUPAC
- N-Phenyl-2-(di-tert-butylphosphino)indole,N-Phenylindol-2-yl-di-tert-butylphosphine,cataCXium® PIntB
- Synonyms
- N-Phenyl-2-(di-tert-butylphosphino)indoleN-Phenylindol-2-yl-di-tert-butylphosphinecataCXium® PIntB
Catalysis
This phosphine ligand is widely employed in palladium-catalysed cross-coupling reactions, including Buchwald-Hartwig amination, Sonogashira coupling, and Suzuki-Miyaura coupling. Its bulky tert-butyl groups and indole backbone provide excellent steric and electronic properties, promoting high yields and selectivity in challenging transformations.
Organic Synthesis
As a key component in catalytic systems, 2-(Di-tert-butylphosphino)-1-phenylindole facilitates the formation of carbon-carbon and carbon-heteroatom bonds. It is instrumental in the synthesis of complex organic molecules relevant to pharmaceuticals, agrochemicals, and materials science.
Ligand Design
The unique structural features of this compound make it a valuable building block in the development of new catalytic systems. Researchers utilise its properties to tune reactivity and selectivity in homogeneous catalysis.
| Molecular weight | 337.44 |
|---|---|
| Empirical formula | C22H28NP |
| Assay | 95% |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionSonogashira CouplingSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary uses of 2-(Di-tert-butylphosphino)-1-phenylindole?
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2-(Di-tert-butylphosphino)-1-phenylindole is primarily used as a ligand in palladium-catalysed cross-coupling reactions such as Buchwald-Hartwig amination, Sonogashira coupling, and Suzuki-Miyaura coupling, facilitating complex organic synthesis.
What is the CAS number and empirical formula for 2-(Di-tert-butylphosphino)-1-phenylindole?
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The CAS number is 740815-37-6 and the empirical formula is C22H28NP.
What grade and purity does Tech Serve Solutions supply for 2-(Di-tert-butylphosphino)-1-phenylindole?
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Tech Serve Solutions supplies 2-(Di-tert-butylphosphino)-1-phenylindole with an assay of 95%. We do not represent this product as meeting USP, BP, EP, or any other pharmacopoeial standards.
What are the safety and handling recommendations for this compound?
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According to GHS data, this compound requires the use of Eyeshields and Gloves. A type N95 (US) or type P1 (EN143) respirator filter is also recommended. It carries a WGK rating of 3 in Germany, indicating a high hazard to water.
How is 2-(Di-tert-butylphosphino)-1-phenylindole typically packed and exported?
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As a specialist supplier, Tech Serve Solutions packs and exports 2-(Di-tert-butylphosphino)-1-phenylindole in compliance with all relevant international shipping and customs regulations for fine chemicals.
How can I request a sample or a quote for 2-(Di-tert-butylphosphino)-1-phenylindole?
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To request a sample or a quote, please contact our sales department through the website or by calling our listed telephone number. Please specify the required quantity and delivery location.
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