2-Chloroethyl chloroformate
2-Chloroethyl chloroformate (CAS 627-11-2), with the linear formula ClCOOCH2CH2Cl and a molecular weight of 142.97 g/mol, is a key organic building block. This acid halide is employed in various chemical synthesis applications. It is supplied by Tech Serve Solutions (TSS) with an assay of 97%. TSS ensures reliable sourcing and export of this chemical for research and industrial needs.
- IUPAC
- 2-Chloroethoxycarbonyl chloride
- Synonyms
- 2-Chloroethoxycarbonyl chloride2-Chloroethyl chlorocarbonate
Synthesis of Oxazolidinones
2-Chloroethyl chloroformate is utilised in the preparation of complex heterocyclic compounds, such as (4S)-4-hydroxymethyl-N-[(αR)-α-methylbenzyl]-2-oxazolidinone, serving as a valuable intermediate in multi-step organic syntheses.
Preparation of Dienamide Precursors
This reagent facilitates the synthesis of propargyl dienamide (II), a crucial precursor for the generation of allenic dienamide, demonstrating its utility in the construction of specialised organic molecules.
Intermediate in Pyrazine Synthesis
It has been employed in the synthesis of substituted dihydropyrrolo[3,4-b]pyrazin-5-ones, such as (±)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo-[3,4-b]-pyrazin-5-one.
| Molecular weight | 142.97 |
|---|---|
| Linear formula | ClCOOCH2CH2Cl |
| Assay | 97% |
| Boiling point | 155-156 °C(lit.) |
| Density | 1.385 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.446(lit.) |
| Vapour pressure | 0.23 psi (20 °C) |
| Storage temperature | 2-8°C |
| Application | 2-Chloroethyl chloroformate has been used in the synthesis of:• (4S)-4-hydroxymethyl-N-[(αR)-α-methylbenzyl]-2-oxazolidinone1• propargyl dienamide (ll), a precursor of allenic dienamide2• (±)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo-[3,4-b]-pyrazin-5-one3 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 70 °C / 158 °F |
| Transport (UN / ADR) | UN 3277 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloroethyl chloroformate used for?
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2-Chloroethyl chloroformate is used as a building block and intermediate in organic synthesis, notably in the preparation of oxazolidinones, dienamide precursors, and certain pyrazine derivatives.
What are the CAS number and formula for 2-Chloroethyl chloroformate?
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The CAS number for 2-Chloroethyl chloroformate is 627-11-2, and its linear formula is ClCOOCH2CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloroethyl chloroformate with a minimum assay of 97%. TSS does not represent this product as USP, BP, EP, or for pharmaceutical, nutraceutical, or food use.
How should 2-Chloroethyl chloroformate be handled safely?
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2-Chloroethyl chloroformate is corrosive and toxic by inhalation. Handle with extreme care in a well-ventilated area or fume hood, wearing appropriate personal protective equipment including a faceshield, goggles, chemical-resistant gloves, and a suitable respirator (e.g., type ABEK filter). Refer to the Safety Data Sheet for comprehensive guidance.
Is 2-Chloroethyl chloroformate suitable for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Chloroethyl chloroformate, adhering to international shipping regulations.
How can I request a quote or sample for 2-Chloroethyl chloroformate?
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Please contact our sales team directly via the website or telephone to request a quotation or to inquire about obtaining a sample of 2-Chloroethyl chloroformate.
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