2-Chloro-6-fluorobenzonitrile
2-Chloro-6-fluorobenzonitrile (CAS: 668-45-1), with the molecular formula ClC6H3(F)CN and a molecular weight of 155.56 g/mol, is a key organic building block. This compound serves as a valuable intermediate in chemical synthesis, particularly in the preparation of more complex fluorinated organic molecules and polymers. Its characteristic structure, featuring both a nitrile and halogen substituents on an aromatic ring, makes it a versatile reagent for various synthetic transformations.
Synthesis of Oxirane Derivatives
2-Chloro-6-fluorobenzonitrile has been utilised in the synthesis of complex organic molecules, including intermediates like <i>rac</i>-2-chloro-6-(oxiran-2-ylmethoxy)benzonitrile, which can be further elaborated in multi-step syntheses.
Polymer Chemistry
The compound finds application in the development of novel polymeric materials. Specifically, it has been employed in the synthesis of high-molecular-weight, soluble polyarylether alternating copolymers that incorporate pendent cyano groups, potentially offering unique material properties.
Fluorinated Organic Synthesis
As an aryl fluorinated building block, 2-Chloro-6-fluorobenzonitrile is integral to synthetic routes requiring the introduction of fluorine and nitrile functionalities into aromatic systems, facilitating the creation of diverse organic compounds.
| Molecular weight | 155.56 |
|---|---|
| Linear formula | ClC6H3(F)CN |
| Assay | ≥98.0% (GC) |
| Boiling point | 104 °C/11 mmHg(lit.) |
| Application | 2-Chloro-6-fluorobenzonitrile was used in the synthesis of:• rac-2-chloro-6-(oxiran-2-ylmethoxy)benzonitrile1• high-molecular-weight, soluble polyarylether alternating copolymers containing pendent cyano groups2 |
| Melting point | 55-59 °C(lit.)55-59 °C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3439 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-6-fluorobenzonitrile used for?
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2-Chloro-6-fluorobenzonitrile is used as a chemical intermediate in organic synthesis, including the preparation of oxirane derivatives and specialized polymers.
What is the CAS number and chemical formula for 2-Chloro-6-fluorobenzonitrile?
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The CAS number is 668-45-1 and the linear chemical formula is ClC6H3(F)CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-6-fluorobenzonitrile with a purity of ≥98.0% (GC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Chloro-6-fluorobenzonitrile be handled safely?
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Handling 2-Chloro-6-fluorobenzonitrile requires appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. It is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, and may cause respiratory irritation. Always consult the Safety Data Sheet (SDS) before use.
How is 2-Chloro-6-fluorobenzonitrile exported and shipped?
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2-Chloro-6-fluorobenzonitrile is exported and shipped according to international regulations for hazardous materials, designated as UN 3439, Class 6.1, Packing Group III.
How can I request a quote or sample for 2-Chloro-6-fluorobenzonitrile?
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To request a quote or a sample of 2-Chloro-6-fluorobenzonitrile, please contact our sales department through the website or direct contact details provided.
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