2-Chloro-5-fluoropyridine
2-Chloro-5-fluoropyridine (CAS: 31301-51-6) is a heterocyclic organic compound with the molecular formula C5H3ClFN and a molecular weight of 131.54 g/mol. This halogenated pyridine derivative serves as a valuable building block in organic synthesis, particularly in the development of fluorinated compounds and complex heterocyclic structures. Its specific reactivity profile makes it a key intermediate for researchers and chemists in various fields, including agrochemicals and pharmaceuticals.

Chemical Synthesis Intermediate
Serves as a crucial building block for the synthesis of more complex organic molecules. Its halogen and fluorine substituents offer versatile reaction sites for derivatization.
Fluorinated Compound Development
A key intermediate in the preparation of novel fluorinated organic compounds, where the fluorine atom imparts unique electronic and pharmacokinetic properties.
Heterocyclic Chemistry Research
Utilised in the construction of diverse heterocyclic frameworks, including those with potential applications in medicinal chemistry and materials science.
| Molecular weight | 131.54 |
|---|---|
| Empirical formula | C5H3ClFN |
| Assay | 95% |
| Density | 1.297 g/mL at 25 °C |
| Refractive index | n20/D 1.503 |



Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 42 °C / 107.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22-37/38-41 |
| Safety statements (S) | 26-36/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-5-fluoropyridine used for?
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2-Chloro-5-fluoropyridine is primarily used as a building block and intermediate in organic synthesis, particularly for creating fluorinated compounds and complex heterocyclic structures within research and development settings.
What are the CAS number and chemical formula for 2-Chloro-5-fluoropyridine?
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The CAS number for 2-Chloro-5-fluoropyridine is 31301-51-6, and its chemical formula is C5H3ClFN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-5-fluoropyridine with an assay of 95%. We do not represent this product as USP, BP, or EP grade; it is supplied for research and laboratory use.
How should 2-Chloro-5-fluoropyridine be handled safely?
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2-Chloro-5-fluoropyridine is a Danger hazard, flammable and can cause skin irritation, serious eye damage, and respiratory irritation. Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area. Refer to the Safety Data Sheet for full details.
How is 2-Chloro-5-fluoropyridine packed and exported?
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2-Chloro-5-fluoropyridine is typically packed according to international shipping regulations for hazardous materials. Tech Serve Solutions exports chemicals globally to support research and industrial needs.
How can I request a quote or sample for 2-Chloro-5-fluoropyridine?
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To request a quote or sample for 2-Chloro-5-fluoropyridine, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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