2-Chloro-5-fluorobenzyl bromide
2-Chloro-5-fluorobenzyl bromide (CAS: 81778-09-8) is a halogenated aromatic compound with the chemical formula ClC6H3(F)CH2Br and a molecular weight of 223.47 g/mol. This versatile building block is primarily utilised in organic synthesis, particularly in the development of novel fluorinated compounds and complex chemical structures. Its reactive benzyl bromide moiety allows for efficient derivatisation in various chemical transformations.
Organic Synthesis Intermediate
This compound serves as a key intermediate in the synthesis of more complex organic molecules. Its structure, featuring both chloro and fluoro substituents on the benzyl ring and a reactive bromide, makes it valuable for introducing specific functionalities.
Pharmaceutical Research
2-Chloro-5-fluorobenzyl bromide is employed in research and development within the pharmaceutical sector. It can be a precursor for the synthesis of active pharmaceutical ingredients (APIs) or their intermediates, particularly where fluorinated aryl motifs are desired.
Material Science Applications
The compound's unique halogenation pattern may find utility in the development of specialised materials. It can be incorporated into polymers or other advanced materials to impart specific chemical or physical properties.
| Molecular weight | 223.47 |
|---|---|
| Linear formula | ClC6H3(F)CH2Br |
| Assay | 99% |
| Boiling point | 65-66 °C/2 mmHg(lit.) |
| Density | 1.654 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.566(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 17 °C / 62.6 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 16-23-26-33-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-5-fluorobenzyl bromide used for?
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2-Chloro-5-fluorobenzyl bromide is primarily used as an intermediate in organic synthesis, particularly in the pharmaceutical and material science industries for creating complex fluorinated compounds.
What are the CAS number and chemical formula for 2-Chloro-5-fluorobenzyl bromide?
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The CAS number is 81778-09-8 and the chemical formula is ClC6H3(F)CH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-5-fluorobenzyl bromide with an assay of 99%. This product is suitable for research and technical applications. We do not represent it as USP, BP, or EP grade.
How should 2-Chloro-5-fluorobenzyl bromide be handled?
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2-Chloro-5-fluorobenzyl bromide is classified as Danger (GHS02, GHS05) and causes severe skin burns and eye damage (H314). It is also a flammable liquid (H225). Handle with appropriate personal protective equipment, including faceshields, goggles, gloves, and suitable respiratory protection. Ensure good ventilation and avoid ignition sources.
Is 2-Chloro-5-fluorobenzyl bromide a controlled substance?
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The provided data does not indicate that 2-Chloro-5-fluorobenzyl bromide is a controlled substance. It is classified as highly flammable and corrosive.
How is 2-Chloro-5-fluorobenzyl bromide packed and shipped?
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This chemical is shipped as UN 2924, Hazard Class 8(3), Packing Group II, indicating it is a corrosive liquid, flammable, n.o.s. Please consult our shipping department for specific details regarding export and packaging.
How can I request a quote or sample for 2-Chloro-5-fluorobenzyl bromide?
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To request a quote or a sample, please visit the Tech Serve Solutions website and use the contact form or product inquiry tool. You can also contact our sales team directly.
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