2-Chloro-5-fluoro-4-methoxypyrimidine
2-Chloro-5-fluoro-4-methoxypyrimidine (CAS: 37554-70-4), with the molecular formula C5H4ClFN2O and a molecular weight of 162.55 g/mol, is a halogenated heterocyclic compound. It serves as a valuable building block in organic synthesis, particularly within the pharmaceutical and agrochemical industries. Its specific structural features make it a key intermediate for the development of novel fluorinated compounds and advanced materials, enabling precise molecular modifications.

Pharmaceutical Intermediate
Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, leveraging its pyrimidine core and halogen substituents for targeted biological activity.
Agrochemical Development
Applicable in the creation of novel pesticides, herbicides, and fungicides, where the fluoropyrimidine moiety can enhance efficacy and metabolic stability.
Organic Synthesis Building Block
A versatile reagent for introducing fluorinated heterocyclic structures into complex organic molecules, facilitating research and development in various chemical fields.
Material Science Research
Potential use in the development of functional materials and specialty chemicals requiring specific electronic or structural properties imparted by the fluorinated pyrimidine ring.
| Molecular weight | 162.55 |
|---|---|
| Empirical formula | C5H4ClFN2O |


Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-5-fluoro-4-methoxypyrimidine used for?
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This compound is primarily utilised as a building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. Its structure is useful for creating complex fluorinated heterocyclic molecules.
What is the CAS number and molecular formula for 2-Chloro-5-fluoro-4-methoxypyrimidine?
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The CAS number is 37554-70-4, and the molecular formula is C5H4ClFN2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research grade material. The exact assay and purity are available on the product's specification sheet. We do not represent this product as USP, BP, or EP grade.
How should 2-Chloro-5-fluoro-4-methoxypyrimidine be handled safely?
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Based on its safety data, 2-Chloro-5-fluoro-4-methoxypyrimidine is classified as Danger (GHS05, GHS07), with hazards including H302 (Harmful if swallowed) and H318 (Causes serious eye damage). Always wear appropriate personal protective equipment, including eye protection (P280, P305 + P351 + P338), and handle in a well-ventilated area.
Is 2-Chloro-5-fluoro-4-methoxypyrimidine available for export?
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Yes, Tech Serve Solutions specialises in supplying and exporting fine chemicals globally. Please contact us for export-specific inquiries.
How can I request a quote or sample?
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To request a quote or a sample, please navigate to the product page and utilise the designated request forms, or contact our sales team directly.
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