Dimethyl (R)-(+)-methylsuccinate
Dimethyl (R)-(+)-methylsuccinate (CAS 22644-27-5), with the molecular formula C7H12O4 and a molecular weight of 160.17 g/mol, is a chiral ester. This compound is a valuable intermediate, notably employed in the synthesis of FK-506. Tech Serve Solutions supplies this chemical with an assay of 99%, suitable for research and chemical synthesis applications.
Synthesis of FK-506
Dimethyl (R)-(+)-methylsuccinate serves as a key building block in the complex multi-step synthesis of FK-506, a macrolide compound with significant immunosuppressive properties. Its chiral nature is critical for establishing the correct stereochemistry in the final product.
Chiral Building Block
As a chiral ester, this compound is useful in asymmetric synthesis. It can be incorporated into diverse organic molecules where specific stereoisomerism is required, facilitating the creation of complex chiral targets in pharmaceutical and fine chemical research.
Organic Synthesis Intermediate
This succinate derivative acts as a versatile intermediate in broader organic synthesis pathways. Its ester functionalities and chiral centre allow for various chemical transformations, enabling access to a range of more complex organic structures.
| Molecular weight | 160.17 |
|---|---|
| Linear formula | CH3O2CCH2CH(CH3)CO2CH3 |
| Assay | 99% |
| Boiling point | 80-81 °C/12 mmHg(lit.) |
| Density | 1.076 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.418(lit.) |
| Optical activity | [α]20/D +4.8°, c = 2.9 in chloroform |
| Application | Used in the synthesis of FK-506.1 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 84 °C / 183.2 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dimethyl (R)-(+)-methylsuccinate used for?
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Dimethyl (R)-(+)-methylsuccinate is primarily used in the synthesis of FK-506 and as a chiral building block in asymmetric synthesis and other organic chemistry applications.
What is the CAS number and chemical formula for Dimethyl (R)-(+)-methylsuccinate?
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The CAS number is 22644-27-5, and its chemical formula is CH3O2CCH2CH(CH3)CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Dimethyl (R)-(+)-methylsuccinate with an assay of 99%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product specifications.
How should Dimethyl (R)-(+)-methylsuccinate be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection (half-mask respirator EU/US, or multi-purpose combination cartridge respirator US). Observe all safety data sheet recommendations.
Is Dimethyl (R)-(+)-methylsuccinate a controlled substance?
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The provided data does not indicate that Dimethyl (R)-(+)-methylsuccinate is a controlled substance.
How is Dimethyl (R)-(+)-methylsuccinate shipped or exported?
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Dimethyl (R)-(+)-methylsuccinate is classified under NA 1993 / PGIII for transport. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample for Dimethyl (R)-(+)-methylsuccinate?
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Please contact Tech Serve Solutions directly through our website or sales department to request a quotation or to arrange for a sample.
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