2-Chloro-3-pyridineboronic acid pinacol ester
2-Chloro-3-pyridineboronic acid pinacol ester (CAS: 452972-11-1) is a valuable organoboron compound with the molecular formula C11H15BClNO2 and a molecular weight of 239.51 g/mol. This white to off-white solid is primarily utilised as a building block in organic synthesis. Its structure makes it particularly useful for introducing the 2-chloro-3-pyridyl moiety into various organic frameworks, commonly via Suzuki-Miyaura cross-coupling reactions in the development of novel pharmaceuticals and agrochemicals.
- IUPAC
- 2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine,2-(2-Chloro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Synonyms
- 2-(2-Chloro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Organic Synthesis Intermediate
Serves as a key intermediate in complex organic syntheses, enabling the formation of carbon-carbon bonds through cross-coupling reactions. Its pyridine and boronate ester functionalities offer versatile reactivity for creating diverse molecular architectures.
Pharmaceutical Development
A crucial reagent in medicinal chemistry for the synthesis of drug candidates. It facilitates the introduction of substituted pyridine rings, which are common pharmacophores found in many biologically active molecules.
Agrochemical Research
Utilised in the discovery and development of new pesticides and herbicides. The structural motif it provides can contribute to the efficacy and selectivity of agrochemical compounds.
Materials Science
Can be employed in the synthesis of specialised organic materials, such as ligands for catalysis or components for functional polymers, where precise structural control is required.
| Molecular weight | 239.51 |
|---|---|
| Empirical formula | C11H15BClNO2 |
| Assay | 97% |
| Melting point | 34-38 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-pyridineboronic acid pinacol ester used for?
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2-Chloro-3-pyridineboronic acid pinacol ester is primarily used as a versatile intermediate in organic synthesis, particularly for the preparation of complex molecules in pharmaceutical and agrochemical research through cross-coupling reactions like the Suzuki-Miyaura coupling.
What is the CAS number and molecular formula?
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The CAS number for 2-Chloro-3-pyridineboronic acid pinacol ester is 452972-11-1, and its molecular formula is C11H15BClNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-3-pyridineboronic acid pinacol ester with an assay of 97%. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeia standards.
How should 2-Chloro-3-pyridineboronic acid pinacol ester be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. This compound may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Ensure good ventilation.
Is this chemical a controlled substance?
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Based on the provided data, 2-Chloro-3-pyridineboronic acid pinacol ester is not listed as a controlled substance.
How is this chemical packed and shipped?
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Tech Serve Solutions professionally packs and ships fine chemicals globally, adhering to all necessary regulations for safe transport.
How can I request a quote or sample?
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Please contact our sales team via the website or direct inquiry to request a quotation or a sample of 2-Chloro-3-pyridineboronic acid pinacol ester.
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