2-Chloro-3-nitrobenzoic acid
2-Chloro-3-nitrobenzoic acid (CAS: 3970-35-2; Formula: ClC6H3(NO2)CO2H) is a chemical compound with a molecular weight of 201.56. This benzoic acid derivative serves as a valuable building block and reagent in organic synthesis. It is primarily utilised in the preparation of complex organic molecules, particularly in the field of medicinal chemistry for the development of novel therapeutic scaffolds. Its defined structure makes it a key intermediate for various chemical transformations.
Synthesis of Indole-Based Scaffolds
2-Chloro-3-nitrobenzoic acid has been employed as a reagent in the synthesis of novel biprivileged molecular scaffolds, specifically tetracyclic indolo-benzodiazepines and indolo-quinoxalines.
Microwave-Promoted Ulmann Condensation
This compound was utilised in a microwave-promoted Ulmann condensation reaction with 2-aminopyridines, demonstrating its utility in efficient coupling reactions.
Organic Synthesis Intermediate
As a functionalised benzoic acid, it serves as a versatile building block for constructing more complex organic molecules in research and development settings.
| Molecular weight | 201.56 |
|---|---|
| Linear formula | ClC6H3(NO2)CO2H |
| Assay | ≥98.0% (T) |
| Application | 2-Chloro-3-nitrobenzoic acid was used as reagent during the synthesis of new biprivileged molecular scaffolds of tetracyclic indolo-benzodiazepines and indolo-quinoxalines1. It was used in a microwave-promoted Ulmann condensation with 2-aminopyridines2. |
| Melting point | 183-187 °C(lit.)183-187 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-nitrobenzoic acid used for?
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2-Chloro-3-nitrobenzoic acid is used as a reagent and building block in organic synthesis, particularly for the preparation of novel molecular scaffolds like indolo-benzodiazepines and indolo-quinoxalines, and in Ulmann condensation reactions.
What is the CAS number and chemical formula for 2-Chloro-3-nitrobenzoic acid?
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The CAS number is 3970-35-2 and the linear chemical formula is ClC6H3(NO2)CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-3-nitrobenzoic acid with an assay of ≥98.0% (T). This product is suitable for research and laboratory use and is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should 2-Chloro-3-nitrobenzoic acid be handled?
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2-Chloro-3-nitrobenzoic acid is classified as a Warning substance and is known to cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves, should be used. Ensure good ventilation.
Is 2-Chloro-3-nitrobenzoic acid a controlled substance?
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Based on the provided data, 2-Chloro-3-nitrobenzoic acid is not listed as a controlled substance.
How can I request a quote or sample?
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To request a quote or sample of 2-Chloro-3-nitrobenzoic acid, please contact the TSS sales team through our website or by calling our customer service line.
How is 2-Chloro-3-nitrobenzoic acid shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, adhering to all relevant shipping and export regulations for compounds like 2-Chloro-3-nitrobenzoic acid.
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