2-Chloro-3-methylthiophene
2-Chloro-3-methylthiophene (CAS: 14345-97-2), with the molecular formula C5H5ClS and a molecular weight of 132.61 g/mol, is a halogenated heterocyclic compound. It serves as a valuable building block in organic synthesis, particularly for the construction of more complex thiophene derivatives. Its applications span various research and development sectors, contributing to advancements in medicinal chemistry and materials science.

Organic Synthesis Intermediate
2-Chloro-3-methylthiophene is utilised as a key intermediate in the synthesis of diverse organic molecules. Its reactive chlorine atom and thiophene ring provide functional handles for various chemical transformations.
Pharmaceutical Research
This compound is employed in the research and development of novel pharmaceutical agents. It can be incorporated into molecular scaffolds targeting various biological pathways.
Materials Science
The thiophene moiety makes it a potential precursor for functional materials, including organic semiconductors and polymers, where electronic or optical properties are desired.
| Molecular weight | 132.61 |
|---|---|
| Empirical formula | C5H5ClS |
| Assay | 97% |
| Boiling point | 147-149 °C(lit.) |
| Density | 1.211 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5400(lit.) |



Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 46 °C / 114.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22-41 |
| Safety statements (S) | 16-26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-3-methylthiophene used for?
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2-Chloro-3-methylthiophene is primarily used as a building block in organic synthesis, for pharmaceutical research, and in materials science applications. It aids in the construction of complex thiophene derivatives and other organic molecules.
What are the CAS number and formula for 2-Chloro-3-methylthiophene?
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The CAS number for 2-Chloro-3-methylthiophene is 14345-97-2, and its molecular formula is C5H5ClS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-3-methylthiophene with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
What are the key safety considerations when handling 2-Chloro-3-methylthiophene?
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2-Chloro-3-methylthiophene is a flammable liquid and vapour (H226), harmful if swallowed (H302), and causes serious eye damage (H318). Always handle with appropriate personal protective equipment, including eyeshields, face shields, and suitable gloves, in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling instructions.
Is 2-Chloro-3-methylthiophene a controlled substance?
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The provided data does not indicate that 2-Chloro-3-methylthiophene is a controlled substance.
How is 2-Chloro-3-methylthiophene packed, shipped, and exported?
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2-Chloro-3-methylthiophene is shipped according to relevant dangerous goods regulations (UN 1993, Hazard Class C3, Packing Group III). TSS offers global export services for this chemical.
How can I request a quote or sample of 2-Chloro-3-methylthiophene?
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Please contact our sales department via the website or by phone to request a quote or a sample of 2-Chloro-3-methylthiophene.
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