2-Bromo-5′-fluoro-2′-methoxyacetophenone
2-Bromo-5′-fluoro-2′-methoxyacetophenone (CAS: 343-04-4) is a fluorinated aromatic ketone with a molecular weight of 247.06 g/mol and the empirical formula C9H8BrFO2. This compound serves as a valuable intermediate in organic synthesis, particularly for the development of novel pharmaceutical agents and complex organic molecules. Its structure, featuring both a bromine atom and a fluorine atom on the aromatic ring along with a methoxy group, offers versatile reactivity for various chemical transformations. This makes it a sought-after building block in chemical research and development.
- IUPAC
- 2-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Pharmaceutical Intermediate
Used as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where fluorinated aromatic moieties are required.
Organic Synthesis Reagent
Enables the introduction of a 5-fluoro-2-methoxyphenyl group into target molecules through various coupling and substitution reactions.
Material Science Research
Potential application in the development of specialized organic materials where its specific electronic and structural properties can be exploited.
Agrochemical Development
Can be utilised in the synthetic pathways for novel agrochemicals requiring fluorinated aromatic structures.
| Molecular weight | 247.06 |
|---|---|
| Empirical formula | C9H8BrFO2 |
| Assay | 97% |
| Melting point | 75-80 °C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-5′-fluoro-2′-methoxyacetophenone used for?
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2-Bromo-5′-fluoro-2′-methoxyacetophenone is primarily used as an intermediate in organic synthesis, especially for developing pharmaceuticals, agrochemicals, and specialized organic materials. It acts as a building block to introduce specific fluorinated aromatic structures into target molecules.
What is the CAS number and formula for 2-Bromo-5′-fluoro-2′-methoxyacetophenone?
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The CAS number is 343-04-4, and its empirical formula is C9H8BrFO2.
What grade and purity does Tech Serve Solutions supply for 2-Bromo-5′-fluoro-2′-methoxyacetophenone?
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Tech Serve Solutions supplies this compound with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Bromo-5′-fluoro-2′-methoxyacetophenone be handled safely?
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This compound is a warning-classified chemical causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335), and is harmful to aquatic life with long-lasting effects (H412). Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection in a well-ventilated area. Avoid release to the environment.
How is 2-Bromo-5′-fluoro-2′-methoxyacetophenone packed, shipped, and exported?
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Products are carefully packed according to international shipping regulations and are exported globally by Tech Serve Solutions, a trusted supplier since 1998.
How can I request a sample or quote for 2-Bromo-5′-fluoro-2′-methoxyacetophenone?
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You can request a sample or obtain a quote by contacting our sales team directly through the website or by calling us. Please specify the quantity required and your delivery details.
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