2′,5′-Difluoroacetophenone
2′,5′-Difluoroacetophenone (CAS: 1979-36-8) is a fluorinated organic ketone with the molecular formula C<sub>8</sub>H<sub>6</sub>F<sub>2</sub>O and a molecular weight of 156.13 g/mol. This compound serves as a valuable building block in organic synthesis, particularly within the realm of fluorinated organic chemistry. Its primary documented application involves its use in the preparation of 2,5-difluorostyrene, contributing to the development of novel materials and complex molecules.
- Synonyms
- F2C6H3COCH3
Preparation of 2,5-Difluorostyrene
2′,5′-Difluoroacetophenone is utilized as a precursor in the synthesis of 2,5-difluorostyrene. This transformation is a key step in generating specific fluorinated aromatic compounds for further chemical elaboration.
Fluorinated Organic Synthesis
As an aryl fluorinated building block, this compound is employed in diverse organic synthesis strategies. The presence of fluorine atoms can significantly influence the electronic and steric properties of resulting molecules, making it useful in medicinal chemistry and materials science research.
Ketone Functional Group Chemistry
The ketone moiety in 2′,5′-Difluoroacetophenone allows for a range of characteristic reactions. This enables its use in various chemical transformations, including nucleophilic additions and condensation reactions, as part of broader synthetic pathways.
| Molecular weight | 156.13 |
|---|---|
| Linear formula | F2C6H3COCH3 |
| Assay | 98% |
| Density | 1.233 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4882(lit.) |
| Application | 2′,5′-Difluoroacetophenone has been used in the preparation of 2,5-difluorostyrene1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2′,5′-Difluoroacetophenone used for?
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2′,5′-Difluoroacetophenone is primarily used as a building block in organic synthesis, notably in the preparation of 2,5-difluorostyrene.
What are the CAS number and chemical formula for 2′,5′-Difluoroacetophenone?
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The CAS number is 1979-36-8 and the linear formula is F₂C₆H₃COCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2′,5′-Difluoroacetophenone with a minimum assay of 98%. This product is intended for laboratory and research use; we do not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should 2′,5′-Difluoroacetophenone be handled safely?
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2′,5′-Difluoroacetophenone is classified as a warning substance that can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator (e.g., type ABEK EN14387 filter), should be used. Ensure adequate ventilation and avoid breathing dust/fume/gas/mist/vapours/spray. In case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present and easy to do. Continue rinsing.
Is 2′,5′-Difluoroacetophenone available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2′,5′-Difluoroacetophenone, and can fulfil international orders.
How can I request a sample or quote for 2′,5′-Difluoroacetophenone?
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To request a sample or a quotation for 2′,5′-Difluoroacetophenone, please contact our sales team through the website or by phone.
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