2′,5′-Dihydroxyacetophenone
2′,5′-Dihydroxyacetophenone (CAS 490-78-8) is an organic compound with the linear formula (HO)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>COCH<sub>3</sub> and a molecular weight of 152.15 g/mol. This white to off-white powder functions as a valuable building block in organic synthesis. Its chemical structure, featuring a ketone group and two hydroxyl substituents on an aromatic ring, makes it suitable for various chemical transformations and applications in research and development settings.
- IUPAC
- 2,5-Dihydroxyphenyl methyl ketone,2-Acetyl-1,4-dihydroxybenzene,2-Acetylhydroquinone,Acetylquinol,Quinacetophenone
- Synonyms
- (HO)2C6H3COCH32,5-Dihydroxyphenyl methyl ketone2-Acetyl-1,4-dihydroxybenzene2-AcetylhydroquinoneAcetylquinolQuinacetophenone

Organic Synthesis Intermediate
2′,5′-Dihydroxyacetophenone serves as a key intermediate in the synthesis of more complex organic molecules. Its reactive functional groups allow for diverse chemical modifications, facilitating the construction of target compounds in multi-step synthetic pathways.
Research and Development
This compound is utilised in research laboratories for exploring new chemical reactions and developing novel materials. Its availability as a building block aids chemists in the design and synthesis of potential pharmaceuticals, agrochemicals, or specialty materials.
Building Block for Heterocycles
The structure of 2′,5′-Dihydroxyacetophenone lends itself to the formation of heterocyclic compounds. The presence of hydroxyl groups and the ketone moiety can participate in cyclisation reactions to yield various ring systems for further chemical investigation.
| Molecular weight | 152.15 |
|---|---|
| Linear formula | (HO)2C6H3COCH3 |
| Assay | 97% |
| Solubility | dioxane: soluble50 mg/mL, clear |
| Melting point | 204-206 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| Cation traces | Ca: ≤20 mg/kgCd: ≤5 mg/kgCo: ≤5 mg/kgCr: ≤5 mg/kgCu: ≤5 mg/kgK: ≤50 mg/kgMg: ≤5 mg/kgMn: ≤5 mg/kgNa: ≤50 mg/kgNi: ≤5 mg/kgPb: ≤5 mg/kgZn: ≤5 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Analyte Suitability | glycanspeptidesproteins |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2′,5′-Dihydroxyacetophenone used for?
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2′,5′-Dihydroxyacetophenone is primarily used as a building block and intermediate in organic synthesis and research and development laboratories for creating more complex molecules.
What is the CAS number and molecular formula for 2′,5′-Dihydroxyacetophenone?
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The CAS number for 2′,5′-Dihydroxyacetophenone is 490-78-8, and its linear formula is (HO)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>COCH<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2′,5′-Dihydroxyacetophenone with an assay of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2′,5′-Dihydroxyacetophenone be handled safely?
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According to GHS, 2′,5′-Dihydroxyacetophenone is a Warning substance and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation.
Is 2′,5′-Dihydroxyacetophenone a controlled substance?
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Based on the provided data, 2′,5′-Dihydroxyacetophenone is not classified as a controlled substance.
How is 2′,5′-Dihydroxyacetophenone packed, shipped, and exported?
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2′,5′-Dihydroxyacetophenone is carefully packed and prepared for global export by Tech Serve Solutions, adhering to international shipping regulations for chemical compounds.
How can I request a quote or sample for 2′,5′-Dihydroxyacetophenone?
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To request a quote or sample for 2′,5′-Dihydroxyacetophenone, please contact the Tech Serve Solutions sales team through our website or by phone.
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