2,5-Bis(trifluoromethyl)aniline
2,5-Bis(trifluoromethyl)aniline (CAS 328-93-8) is a fluorinated aromatic amine with the molecular formula (CF3)2C6H3NH2 and a molecular weight of 229.12 g/mol. This compound serves as a valuable building block in organic synthesis. Its distinct structure, featuring two trifluoromethyl groups on an aniline core, makes it useful in the development of advanced materials and complex chemical intermediates.
- Synonyms
- (CF3)2C6H3NH2

Organic Synthesis Intermediate
2,5-Bis(trifluoromethyl)aniline is employed as a key intermediate in the synthesis of diverse organic compounds. Its reactivity allows for further functionalization in the creation of more complex molecules for research and development.
Pharmaceutical Research
This aniline derivative is utilised in the exploratory stages of pharmaceutical research. The presence of trifluoromethyl groups can significantly influence the pharmacokinetic and pharmacodynamic properties of potential drug candidates.
Agrochemical Development
The compound finds application in the design and synthesis of novel agrochemicals. Its unique structural features can contribute to the efficacy and targeted action of pesticides and herbicides.
Materials Science
2,5-Bis(trifluoromethyl)aniline is used in the development of specialty polymers and functional materials. The fluorine content can impart desirable properties such as thermal stability and chemical resistance.
| Molecular weight | 229.12 |
|---|---|
| Linear formula | (CF3)2C6H3NH2 |
| Assay | 99% |
| Boiling point | 70-71 °C/15 mmHg(lit.) |
| Density | 1.467 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.432(lit.) |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 71 °C / 159.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Bis(trifluoromethyl)aniline used for?
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2,5-Bis(trifluoromethyl)aniline is primarily used as an intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and advanced materials.
What is the CAS number and chemical formula for 2,5-Bis(trifluoromethyl)aniline?
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The CAS number is 328-93-8 and the chemical formula is (CF3)2C6H3NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,5-Bis(trifluoromethyl)aniline with an assay of 99%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,5-Bis(trifluoromethyl)aniline be handled?
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Handle 2,5-Bis(trifluoromethyl)aniline with appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator. Avoid breathing dust, fumes, gas, mist, vapours, or spray. It is classified with hazards including H302, H312, H315, H319, H332, and H335.
How is 2,5-Bis(trifluoromethyl)aniline packed and shipped?
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2,5-Bis(trifluoromethyl)aniline is packed and shipped according to international regulations for hazardous materials. As an exporter, TSS ensures compliance with all necessary shipping requirements for global distribution.
How can I request a quote or sample for 2,5-Bis(trifluoromethyl)aniline?
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To request a quote or a sample of 2,5-Bis(trifluoromethyl)aniline, please contact our sales department through the website or provide your details via the enquiry form.
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