2,4,6-Trimethylbenzoyl chloride
2,4,6-Trimethylbenzoyl chloride (CAS 938-18-1) is an organic compound featuring an acid halide functional group. With a molecular weight of 182.65 g/mol, this substance serves as a versatile building block in organic synthesis. Its reactivity makes it suitable for introducing the 2,4,6-trimethylbenzoyl moiety into various molecules, facilitating the construction of complex organic structures for research and development purposes.
- Synonyms
- 938-18-1(CH3)3(C6H2)C(O)Cl

Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of more complex organic molecules. Its acid chloride functionality readily participates in acylation reactions, enabling the formation of esters, amides, and other carbonyl derivatives.
Building Block for Novel Compounds
Serves as a valuable building block for the development of new chemical entities. The sterically hindered trimethylbenzoyl group can impart unique properties to the final compounds, making it useful in materials science and medicinal chemistry research.
Reagent in Acylation Reactions
Employed as a reagent in various acylation reactions due to the electrophilic nature of the carbonyl carbon. It reacts with nucleophiles such as alcohols, amines, and phenols to form corresponding acyl compounds.
| Molecular weight | 182.65 |
|---|---|
| Linear formula | (CH3)3(C6H2)C(O)Cl |
| Assay | 97% |
| Density | 1.095 g/mL at 25 °C |
| Refractive index | n20/D 1.529 |
| Storage temperature | 2-8°C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Trimethylbenzoyl chloride primarily used for?
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2,4,6-Trimethylbenzoyl chloride is primarily used as a building block and intermediate in organic synthesis, particularly in acylation reactions to introduce the 2,4,6-trimethylbenzoyl group into molecules.
What are the CAS number and formula for 2,4,6-Trimethylbenzoyl chloride?
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The CAS number for 2,4,6-Trimethylbenzoyl chloride is 938-18-1. Its linear formula is (CH₃)₃(C₆H₂)C(O)Cl.
What grade and purity does Tech Serve Solutions supply for 2,4,6-Trimethylbenzoyl chloride?
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Tech Serve Solutions supplies 2,4,6-Trimethylbenzoyl chloride with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 2,4,6-Trimethylbenzoyl chloride be handled safely?
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2,4,6-Trimethylbenzoyl chloride is a corrosive substance (H314) that causes severe skin burns and eye damage. Handling requires appropriate personal protective equipment, including gloves, goggles, a face shield, and a suitable respirator. Work should be conducted in a well-ventilated area.
How is 2,4,6-Trimethylbenzoyl chloride packed and exported?
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This chemical is packed and exported according to international shipping regulations for hazardous materials, classified under UN 3265, Class 8, Packing Group II.
How can I request a quote or sample for 2,4,6-Trimethylbenzoyl chloride?
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To request a quote or a sample, please contact our sales department through the website or by phone, providing your contact details and the product CAS number (938-18-1).
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