2,3,4,5-Tetrafluoroaniline
2,3,4,5-Tetrafluoroaniline (CAS 5580-80-3), with the molecular formula HC6F4NH2 and a molecular weight of 165.09 g/mol, is a fluorinated aromatic amine. This compound serves as a valuable building block in organic synthesis, particularly for creating complex fluorinated molecules. Its primary application lies in the synthesis of polyfluorinated quinolines, contributing to advancements in materials science and medicinal chemistry.
- Synonyms
- 5-TetrafluoroanilineHC6F4NH2

Synthesis of Polyfluorinated Quinolines
2,3,4,5-Tetrafluoroaniline is a key intermediate in the synthesis of polyfluorinated quinoline derivatives. These compounds are of interest for their potential applications in pharmaceuticals and advanced materials.
Fluorinated Aromatic Building Block
As a fluorinated aryl building block, this aniline derivative offers a versatile platform for introducing tetrafluorinated phenyl rings into various organic structures, enabling the development of novel chemical entities.
Organic Synthesis Intermediate
This compound is utilized in complex organic synthesis pathways, providing a reactive amine group on a highly fluorinated benzene ring. It is suitable for research and development in synthetic chemistry.
| Molecular weight | 165.09 |
|---|---|
| Linear formula | HC6F4NH2 |
| Assay | 98% |
| Boiling point | 78 °C/13 mmHg(lit.) |
| Application | 2,3,4,5-Tetrafluoroaniline can be used in the synthesis of polyfluorinated quinolines1. |
| Melting point | 27-29 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 79 °C / 174.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,3,4,5-Tetrafluoroaniline used for?
+
2,3,4,5-Tetrafluoroaniline is primarily used as a building block in organic synthesis, notably for the preparation of polyfluorinated quinolines.
What is the CAS number and formula for 2,3,4,5-Tetrafluoroaniline?
+
The CAS number is 5580-80-3, and the linear formula is HC6F4NH2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 2,3,4,5-Tetrafluoroaniline with a minimum assay of 98%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeial grades.
What are the primary safety concerns when handling 2,3,4,5-Tetrafluoroaniline?
+
2,3,4,5-Tetrafluoroaniline is classified as a warning substance with hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including dust masks (type N95 US), eyeshields, and gloves, should be used. Ensure adequate ventilation.
How is 2,3,4,5-Tetrafluoroaniline supplied and exported?
+
Tech Serve Solutions, as a specialist global supplier and exporter, ensures that 2,3,4,5-Tetrafluoroaniline is packaged and shipped according to international regulations for chemical transport.
How can I request a quote or sample of 2,3,4,5-Tetrafluoroaniline?
+
To request a quote or a sample of 2,3,4,5-Tetrafluoroaniline, please contact the Tech Serve Solutions sales team through our website or direct inquiry channels.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis