2,3,4,5,6-Pentafluorobenzoyl chloride
2,3,4,5,6-Pentafluorobenzoyl chloride (CAS: 2251-50-5; Formula: C6F5COCl) is a fluorinated aromatic acyl chloride with a molecular weight of 230.52. It serves as a key reagent in organic synthesis, particularly for acylation reactions and the derivatisation of various analytes. Its utility extends to analytical chemistry, where it is employed in the development of sensitive detection methods for compounds such as steroids and amines, and in biochemical research.
- IUPAC
- Pentafluorobenzoic acid chloride,Perfluorobenzoyl chloride
- Synonyms
- 5,6-Pentafluorobenzoyl chlorideC6F5COClPentafluorobenzoic acid chloridePerfluorobenzoyl chloride
Steroid Analysis
Used for the derivatisation of steroids like testosterone, estradiol, and estrone, enabling their quantitative determination in biological samples using gas chromatography.
Amine Detection
Employed in developing GC-MS methods for the accurate determination of dimethylamine (DMA) in human urine samples.
Microbial Identification
Utilised in gas chromatography/mass spectrometry techniques to detect specific bacteria, such as Enterobacter cloacae, within cultures.
Organic Synthesis Reagent
Acts as an acylating agent in chemical synthesis, facilitating the introduction of the pentafluorobenzoyl group into various organic molecules.
| Molecular weight | 230.52 |
|---|---|
| Linear formula | C6F5COCl |
| Boiling point | 158-159 °C(lit.) |
| Density | 1.601 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.453(lit.) |
| Storage temperature | 2-8°C |
| Application | 2,3,4,5,6-Pentafluorobenzoyl chloride was used for derivatization of 5-androstenediol, testosterone, estradiol , dihydrotestosterone and estrone in a study to determine their serum levels1. 2,3,4,5,6-Pentafluorobenzoyl chloride was used to derivatize dimethylamine(DMA) in study to develop a rapid and accurate GC–MS method for determination of DMA in human urine2. 2,3,4,5,6-Pentafluorobenzoyl chloride was used in a study to detect the presence of Enterobacter cloacae in cultures of Leuconostoc mesenteroide by gas chromatography/mass spectrometry3. |
Hazard statements
- H314Causes severe skin burns and eye damage
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,3,4,5,6-Pentafluorobenzoyl chloride primarily used for?
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It is primarily used as a derivatisation reagent in analytical chemistry for the sensitive detection of steroids and amines, and as an acylating agent in organic synthesis.
What is the CAS number and molecular formula for 2,3,4,5,6-Pentafluorobenzoyl chloride?
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The CAS number is 2251-50-5 and the molecular formula is C6F5COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research grade material. We do not represent it as USP, BP, or EP grade. Please contact us for specific purity details.
How should 2,3,4,5,6-Pentafluorobenzoyl chloride be handled safely?
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This compound is corrosive and reacts violently with water. Handle with extreme care, wearing appropriate personal protective equipment including face shields, gloves, and respirators. Ensure adequate ventilation and avoid contact with moisture.
How is 2,3,4,5,6-Pentafluorobenzoyl chloride packed and shipped?
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It is shipped as a hazardous material (UN 3265, Class 8, Packing Group II) and is stored under refrigeration. Please consult our shipping department for specific export and packing details.
How can I request a sample or a quote for 2,3,4,5,6-Pentafluorobenzoyl chloride?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing your specific requirements.
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