2,3,4,5,6-Pentafluorobenzaldehyde

CAS 653-37-2C6F5CHOChemical Synthesis

2,3,4,5,6-Pentafluorobenzaldehyde (CAS: 653-37-2) is a fluorinated aromatic building block with the molecular formula C6F5CHO. It serves as a valuable intermediate in organic synthesis, particularly in the creation of advanced materials and in analytical chemistry. Its applications range from the development of high molecular weight fluorinated polymers through polyhydroxylation to its use as a derivatization reagent for sensitive amine analysis in environmental samples.

Synonyms: 5,6-PentafluorobenzaldehydeC6F5CHO

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2,3,4,5,6-Pentafluorobenzaldehyde (C6F5CHO) — chemical structure, CAS 653-37-2; Chemistry, fine chemical supplied by Tech Serve Solutions

AldehydesBuilding BlocksC7-C8Carbonyl CompoundsChemical SynthesisFluorinated Building BlocksOrganic Building Blocks

01 /Applications

Synthesis of Fluorinated Polymers

Used in superacid-catalyzed polyhydroxylation reactions for the synthesis of novel, high molecular weight fluorinated aromatic polymers.

Analytical Derivatization Reagent

Employed as a derivatization reagent for the sensitive determination of primary amines in sewage sludge using headspace solid-phase microextraction and GC-MS.

Organic Synthesis Intermediate

A versatile building block in organic chemistry for introducing the pentafluorobenzoyl group into various molecular structures.

02 /Properties

Molecular weight	196.07
Linear formula	C6F5CHO
Assay	98%
Boiling point	164-166 °C(lit.)
Density	1.588 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.45(lit.)
Application	2,3,4,5,6-Pentafluorobenzaldehyde was used in the synthesis of novel, high molecular weight fluorinated aromatic polymers by superacid-catalyzed polyhydroxylation reaction of fluorinated carbonyl-containing compounds1. 2,3,4,5,6-Pentafluorobenzaldehyde was used as derivatization reagent in a study to develop a sensitive method for the determination of primary amines in sewage sludge by headspace solid-phase microextraction and gas chromatography-tandem mass spectrometry2.
Melting point	24-28 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Flash point	77 °C / 170.6 °F
Transport (UN / ADR)	UN 2810 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20-36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

653-37-2

MDL number

MFCD00003303

PubChem substance

24846620

Beilstein registry

1876550

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2,3,4,5,6-Pentafluorobenzaldehyde used for?

It is used as a building block in organic synthesis, particularly for creating fluorinated polymers and as a derivatization reagent in analytical chemistry for detecting primary amines.

What is the CAS number and chemical formula for 2,3,4,5,6-Pentafluorobenzaldehyde?

The CAS number is 653-37-2, and the molecular formula is C6F5CHO.

What is the purity or grade of 2,3,4,5,6-Pentafluorobenzaldehyde supplied by TSS?

This chemical is supplied at a minimum assay of 98%.

What are the main hazards associated with 2,3,4,5,6-Pentafluorobenzaldehyde?

It is classified with Warning signal word, and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), H332 (harmful if inhaled), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including dust masks, eyeshields, and gloves, should be used.

How is 2,3,4,5,6-Pentafluorobenzaldehyde packed and shipped?

It is typically packed in suitable containers for chemical transport and shipped according to relevant regulations, including UN 2810 classification for toxic solid, organic, n.o.s.

How can I request a quote for 2,3,4,5,6-Pentafluorobenzaldehyde?

To request a quote, please contact our sales team with the product name (2,3,4,5,6-Pentafluorobenzaldehyde), CAS number (653-37-2), and the required quantity.