2,5-Difluoroaniline
2,5-Difluoroaniline (CAS 367-30-6), with the linear formula F2C6H3NH2 and a molecular weight of 129.11 g/mol, is a fluorinated aromatic amine. It serves as a key building block in organic synthesis, particularly for creating complex molecules. This compound is valuable in the development of pharmaceuticals, agrochemicals, and specialised materials due to the unique properties imparted by the fluorine atoms. Its reactivity and structural features make it an important intermediate for various chemical transformations.
- Synonyms
- F2C6H3NH2
Synthesis of Phenolic Compounds
2,5-Difluoroaniline has been utilised in the synthesis of specific phenolic compounds, such as 2,4-di-tert-butyl-6-[(2,5-difluorophenyl)iminomethyl]phenol. This application highlights its role in constructing functionalised organic molecules.
Preparation of Diazabutadienes
The compound was employed in the ultrasound-assisted preparation of 1,4-diazabutadienes. This demonstrates its utility in reactions requiring specific nitrogen-containing heterocyclic structures.
Fluorinated Organic Synthesis
As a fluorinated building block, 2,5-Difluoroaniline is integral to synthesising diverse organic molecules where fluorine substitution is desired for modulating properties like metabolic stability or lipophilicity.
| Molecular weight | 129.11 |
|---|---|
| Linear formula | F2C6H3NH2 |
| Assay | 99.5% |
| Boiling point | 176-178 °C(lit.) |
| Density | 1.288 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.513(lit.) |
| Application | 2,5-Difluoroaniline was used in the synthesis of 2,4-di-tert-butyl-6-[(2,5-difluorophenyl)iminomethyl]phenol1. It was also used in ultrasound-assisted preparation of 1,4-diazabutadienes2. |
| Melting point | 11-13 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H317May cause an allergic skin reaction
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 66 °C / 150.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 28-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Difluoroaniline used for?
+
2,5-Difluoroaniline is primarily used as a building block in organic synthesis, particularly for creating fluorinated organic molecules, pharmaceuticals, agrochemicals, and specialised materials. It has been used in the synthesis of specific phenolic compounds and in the preparation of 1,4-diazabutadienes.
What is the CAS number and chemical formula for 2,5-Difluoroaniline?
+
The CAS number for 2,5-Difluoroaniline is 367-30-6, and its linear chemical formula is F2C6H3NH2.
What grade and purity does Tech Serve Solutions supply for 2,5-Difluoroaniline?
+
Tech Serve Solutions supplies 2,5-Difluoroaniline with a minimum assay of 99.5%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the primary safety concerns when handling 2,5-Difluoroaniline?
+
2,5-Difluoroaniline is classified with GHS07 symbol and a 'Warning' signal word. It is harmful if swallowed (H302), harmful in contact with skin (H312), may cause an allergic skin reaction (H317), and harmful if inhaled (H332). Appropriate personal protective equipment, including gloves, eyeshields, and suitable respiratory protection, must be used.
How is 2,5-Difluoroaniline typically packed and shipped?
+
2,5-Difluoroaniline is packed in compliance with relevant regulations for chemical transport and is exported globally by Tech Serve Solutions.
How can I request a quote or sample for 2,5-Difluoroaniline?
+
To request a quote or sample for 2,5-Difluoroaniline, please contact the Tech Serve Solutions sales team through our website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis