(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol
(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol (CAS 28143-91-1) is a chiral building block with the linear formula C6H5CH(OH)CH(NH2)CH2OH and a molecular weight of 167.21 g/mol. This compound serves as a key precursor for the synthesis of chiral 2-oxazolines and is employed as an auxiliary in their preparation from carboxylic acid derivatives. Its stereospecific nature makes it valuable in asymmetric synthesis and fine chemical production.
- IUPAC
- L-(+)-threo-2-Amino-1-phenyl-1,3-propanediol
- Synonyms
- 28143-91-1C6H5CH(OH)CH(NH2)CH2OHL-(+)-threo-2-Amino-1-phenyl-1,3-propanediol
Chiral 2-Oxazoline Synthesis
This compound is a vital precursor for the stereoselective synthesis of chiral 2-oxazolines. It facilitates their preparation from various carboxylic acid derivatives, enabling access to important chiral intermediates.
Auxiliary in Asymmetric Synthesis
Utilised as a chiral auxiliary, (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol aids in controlling stereochemistry during organic transformations. This is particularly useful in the preparation of enantiomerically enriched molecules.
Organic Building Block
As a versatile organic building block, it can be incorporated into more complex molecular architectures. Its defined stereochemistry is advantageous for constructing chiral targets in multi-step syntheses.
| Molecular weight | 167.21 |
|---|---|
| Linear formula | C6H5CH(OH)CH(NH2)CH2OH |
| Assay | 97% |
| Optical activity | [α]25/D +37°, c = 1 in 1 M HCl |
| Application | Precursor to chiral 2-oxazolines.1 Auxiliary for the preparation of chiral 2-oxazolines from carboxylic acid derivatives.2 |
| Melting point | 109-113 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol used for?
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This compound is primarily used as a precursor to chiral 2-oxazolines and as an auxiliary for their preparation from carboxylic acid derivatives, making it valuable in asymmetric synthesis.
What are the CAS number and formula for (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol?
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The CAS number is 28143-91-1, and the linear formula is C6H5CH(OH)CH(NH2)CH2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol be handled?
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This compound is classified as a warning substance (GHS07) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Always use appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation.
Is this chemical a controlled substance?
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The provided safety data does not indicate that this chemical is a controlled substance.
How is this chemical packed and exported?
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Tech Serve Solutions professionally packs and exports fine chemicals globally, adhering to all necessary regulations for safe transport.
How can I request a sample or quote for (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol?
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Please contact our sales team directly via phone or email to request a sample or a detailed quotation.
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