(1S,2R)-(+)-Norephedrine
(1S,2R)-(+)-Norephedrine (CAS: 37577-28-9) is a chiral alkaloid with the molecular formula C6H5CH(OH)CH(CH3)NH2 and a molecular weight of 151.21 g/mol. This compound is valuable in asymmetric synthesis and chemical research. It is often employed as a chiral auxiliary due to its specific stereochemistry. TSS supplies this high-purity chemical for various laboratory and research applications, ensuring quality and reliability for scientific endeavours.
- IUPAC
- (1S,2R)-2-Amino-1-phenyl-1-propanol,erythro-α-(1-aminoethyl)benzyl alcohol,D-(+)-Norephedrine,Phenylpropanolamine
- Synonyms
- (1S,2R)-2-Amino-1-phenyl-1-propanolerythro-α-(1-aminoethyl)benzyl alcoholD-(+)-NorephedrinePhenylpropanolamine
Chiral Auxiliary in Asymmetric Synthesis
(1S,2R)-(+)-Norephedrine serves as a crucial chiral auxiliary in stereoselective reactions. Its defined stereocentres enable the control of chirality in the synthesis of complex molecules, particularly in pharmaceutical research and development.
Research and Development
This compound is utilized in academic and industrial research settings for exploring new synthetic methodologies and developing novel chemical entities. Its specific stereoisomeric form makes it a key component in chiral recognition studies.
Intermediate for Pharmaceutical Synthesis
As a derivative of ephedrine, (1S,2R)-(+)-Norephedrine can be a precursor or intermediate in the synthesis of various pharmaceutically active compounds. Its structural features are relevant in medicinal chemistry.
| Molecular weight | 151.21 |
|---|---|
| Linear formula | C6H5CH(OH)CH(CH3)NH2 |
| Assay | 98% |
| Optical activity | [α]20/D +40°, c = 7 in 1 M HCl |
| Storage temperature | 2-8°C |
| Melting point | 51-54 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S,2R)-(+)-Norephedrine used for?
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(1S,2R)-(+)-Norephedrine is primarily used as a chiral auxiliary in asymmetric synthesis and in various chemical research and development applications. It can also serve as an intermediate in the synthesis of other compounds.
What are the CAS number and chemical formula for (1S,2R)-(+)-Norephedrine?
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The CAS number is 37577-28-9 and the linear chemical formula is C6H5CH(OH)CH(CH3)NH2.
What grade and purity does Tech Serve Solutions supply for (1S,2R)-(+)-Norephedrine?
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Tech Serve Solutions supplies (1S,2R)-(+)-Norephedrine with an assay of 98%. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should (1S,2R)-(+)-Norephedrine be handled safely?
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Handle (1S,2R)-(+)-Norephedrine with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. It is classified as harmful if swallowed and causes skin and eye irritation.
Is (1S,2R)-(+)-Norephedrine a controlled substance?
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Based on the provided data, there is no explicit indication that (1S,2R)-(+)-Norephedrine is a controlled substance. However, users should always verify current local regulations.
How is (1S,2R)-(+)-Norephedrine typically shipped and exported?
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As a global supplier, Tech Serve Solutions is experienced in exporting fine chemicals like (1S,2R)-(+)-Norephedrine, adhering to all necessary international shipping and customs regulations for research chemicals.
How can I request a quote or sample for (1S,2R)-(+)-Norephedrine?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through the website or by phone, providing your specific requirements.
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