1H-Indazole-5-boronic acid
1H-Indazole-5-boronic acid (CAS: 338454-14-1) is an organoboron compound with the formula C7H7BN2O2 and a molecular weight of 161.95 g/mol. This heteroaryl boronic acid serves as a key building block in organic synthesis. It is primarily utilised as a reactant for the preparation of diverse biologically active molecules, including kinase inhibitors and receptor affectors, contributing to advancements in medicinal chemistry and drug discovery.
- IUPAC
- 1H-Indazol-5-yl-5-boronic acid,Indazole-5-boronic acid
- Synonyms
- 1H-Indazol-5-yl-5-boronic acid,Indazole-5-boronic acid
Preparation of Thieno[3,2-d]pyrimidines
1H-Indazole-5-boronic acid is employed as a reactant in the preparation of thieno[3,2-d]pyrimidine derivatives, which have been investigated as inhibitors of Tpl2 kinase.
Synthesis of Pyridinyl Benzonaphthyridinones
This boronic acid is a key intermediate in the synthesis of pyridinyl benzonaphthyridinones. These compounds are explored as mTOR inhibitors with potential applications in cancer therapy.
Development of Bisphosphonate Inhibitors
It serves as a reactant in the synthesis of novel bisphosphonate inhibitors designed to target human farnesyl pyrophosphate synthase, a critical enzyme in biological pathways.
Preparation of Diazabicycloheptanes
1H-Indazole-5-boronic acid is used in the preparation of diazabicycloheptane structures, which are studied for their potential as alpha-7 neuronal nicotinic receptor affectors.
Synthesis of Pyrazolopyrimidinamine Derivatives
The compound is a reactant in the preparation of pyrazolopyrimidinamine derivatives. These molecules exhibit inhibitory activity against tyrosine and phosphoinositide kinases.
| Molecular weight | 161.95 |
|---|---|
| Empirical formula | C7H7BN2O2 |
| Assay | ≥95% |
| Application | Reactant for:• Preparation of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors1• Synthesis of pyridinyl benzonaphthyridinones as mTOR inhibitors for the treatment of cancer2• Novel bisphosphonate inhibitors of human farnesyl pyrophosphate synthase3• Preparation of diazabicycloheptanes as α7 neurinal nicotinic receptor affectors4• Preparation of pyrazolopyrimidinamine derivatives with tyrosine and phosphinositide kinase inhibitory activity5 |
| Melting point | 175-180 °C |
Hazard statements
- H302Harmful if swallowed
| Water hazard class (WGK, DE) | 1 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1H-Indazole-5-boronic acid used for?
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1H-Indazole-5-boronic acid is used as a reactant in organic synthesis, particularly for preparing compounds with potential pharmaceutical applications, such as kinase inhibitors and receptor affectors.
What are the CAS number and formula for 1H-Indazole-5-boronic acid?
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The CAS number is 338454-14-1 and the empirical formula is C7H7BN2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1H-Indazole-5-boronic acid with an assay of ≥95%. This product is not supplied as USP, BP, EP, or other pharmacopoeia grades.
How should 1H-Indazole-5-boronic acid be handled?
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1H-Indazole-5-boronic acid is classified with the signal word 'Warning' and carries the hazard statement H302 (Harmful if swallowed). It should be handled with appropriate personal protective equipment in a well-ventilated area, avoiding ingestion.
Is 1H-Indazole-5-boronic acid available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1H-Indazole-5-boronic acid.
How can I request a quote or sample?
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To request a quote or sample of 1H-Indazole-5-boronic acid, please contact our sales team through the website or by phone.
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