1-Piperazinepropanol
1-Piperazinepropanol (CAS 5317-32-8), with the molecular formula C7H16N2O and a molecular weight of 144.21 g/mol, is a versatile heterocyclic building block. This compound, featuring a piperazine ring substituted with a propanol chain, serves as a key reactant in the synthesis of various biologically active molecules. Its applications span the development of pharmaceuticals, including antiviral agents and enzyme inhibitors.
- IUPAC
- 1-(3-Hydroxy-1-propyl)piperazine,1-(3-Hydroxypropyl)-4-piperazine,1-(3-Hydroxypropyl)piperazine,3-(1-Piperazinyl)-1-propanol,3-(1-Piperazinyl)propanol,4-(3-Hydroxypropyl)piperazine,N-(3-Hydroxypropyl)piperazine
- Synonyms
- 1-(3-Hydroxy-1-propyl)piperazine1-(3-Hydroxypropyl)-4-piperazine1-(3-Hydroxypropyl)piperazine3-(1-Piperazinyl)-1-propanol3-(1-Piperazinyl)propanol4-(3-Hydroxypropyl)piperazineN-(3-Hydroxypropyl)piperazine
Synthesis of HRV-3 Inhibitors
Used as a reactant in the preparation of chloropyridazine piperazines, which have demonstrated inhibitory activity against human rhinovirus (HRV-3).
Development of Hsp90 Inhibitors
Serves as a precursor for the synthesis of arylbenzoylpyrrolidine derivatives, investigated for their Hsp90 inhibitory potential.
Serotonin-4 Receptor Antagonist Synthesis
Employed in the creation of novel pyrrolothienopyrazines, which act as antagonists for serotonin-4 receptors.
γ-Secretase Inhibitor Development
Facilitates the preparation of carbamate-functionalized piperidine derivatives, explored as conformationally restricted and orally active γ-secretase inhibitors.
| Molecular weight | 144.21 |
|---|---|
| Empirical formula | C7H16N2O |
| Assay | 97% |
| Application | Reactant for preparation of biologically active molecules:• Preparation of chloropyridazine piperazines as human rhinovirus (HRV-3) inhibitors1• Synthesis of arylbenzoylpyrrolidine derivatives and their Hsp90 inhibitory activity2• Synthesis of pyrrolothienopyrazines as novel serotonin-4 receptors antagonists3• Preparation of carbamate-functionalized 2,6-disubstituted N-(arylsulfonyl) piperidines as conformationally restricted and orally active γ-secretase inhibitors4 |
| Melting point | 49-53 °C(lit.) |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 2 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Piperazinepropanol used for?
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1-Piperazinepropanol is used as a reactant in the synthesis of biologically active molecules, including inhibitors for human rhinovirus (HRV-3) and Hsp90, as well as serotonin-4 receptor antagonists and gamma-secretase inhibitors.
What are the CAS number and formula for 1-Piperazinepropanol?
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The CAS number for 1-Piperazinepropanol is 5317-32-8, and its molecular formula is C7H16N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Piperazinepropanol with a minimum purity of 97%. This product is supplied for research and laboratory use and is not represented as USP, BP, or EP grade.
What are the safety and handling precautions for 1-Piperazinepropanol?
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1-Piperazinepropanol is classified with the GHS symbol GHS07 and the signal word Warning. It has hazard statement H319, indicating it causes serious eye irritation. Appropriate personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter.
How is 1-Piperazinepropanol shipped and exported?
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1-Piperazinepropanol is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a sample or quote for 1-Piperazinepropanol?
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To request a sample or a quote for 1-Piperazinepropanol, please contact the Tech Serve Solutions sales team through the website or by phone.
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