25-Hydroxycholesterol
25-Hydroxycholesterol (CAS 2140-46-7), with the molecular formula C27H46O2 and a molecular weight of 402.65, is a vital oxysterol. It plays a role in cellular processes, including lipid metabolism and signalling pathways. This compound is frequently utilized in scientific research, particularly in studies concerning cancer, cell biology, and metabolic pathways, serving as a key reagent for investigating cholesterol and bile acid metabolism.
- IUPAC
- 5-Cholestene-3β,25-diol
- Synonyms
- 5-Cholestene-3β,25-diol
Cell Signalling and Metabolism Research
25-Hydroxycholesterol is employed in studies investigating cellular signalling pathways, such as the activation of ABCA1 in neuroblastoma cells, and in research focused on fatty acid and lipid metabolism.
Cancer Research Studies
As an anti-proliferative and antitumor agent, 25-Hydroxycholesterol is used in cancer research to explore its effects on cell growth and tumour progression.
Biochemical and Reagent Applications
This compound serves as a valuable biochemical reagent for researchers investigating sterol lipids, bile acid metabolism, and broader metabolomic studies.
| Molecular weight | 402.65 |
|---|---|
| Empirical formula | C27H46O2 |
| Assay | ≥98% |
| Application | 25-Hydroxycholesterol was used to treat mouse neuroblastoma cells to activate the ABCA1 signaling1 and in studies related to fatty acid metabolism.2,3 |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-48 |
| Safety statements (S) | 26-36-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 25-Hydroxycholesterol used for?
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25-Hydroxycholesterol is primarily used in scientific research, including studies on cell signalling, lipid metabolism, cancer research, and as a biochemical reagent for exploring metabolic pathways and sterol lipids.
What are the CAS number and chemical formula for 25-Hydroxycholesterol?
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The CAS number for 25-Hydroxycholesterol is 2140-46-7, and its empirical formula (Hill notation) is C27H46O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 25-Hydroxycholesterol with an assay of ≥98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 25-Hydroxycholesterol be handled safely?
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25-Hydroxycholesterol is a warning substance (GHS07, GHS08) and can be harmful if swallowed, inhaled, or in contact with skin, and may cause skin and eye irritation. Handle with appropriate personal protective equipment (gloves, eye protection) in a well-ventilated area to avoid inhalation. Refer to the safety data sheet for comprehensive handling information.
Is 25-Hydroxycholesterol a controlled substance?
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Based on the provided data, 25-Hydroxycholesterol is not indicated as a controlled substance.
How is 25-Hydroxycholesterol packed and shipped?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details for 25-Hydroxycholesterol will be provided upon request, adhering to all relevant regulations for international chemical trade.
How can I request a quote or sample for 25-Hydroxycholesterol?
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To request a quote or a sample of 25-Hydroxycholesterol, please contact our sales team through our website or by phone, providing your specific requirements.
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