1-Bromo-2-butanone
1-Bromo-2-butanone (CAS: 816-40-0) is a chemical compound with the linear formula C2H5COCH2Br and a molecular weight of 151.00 g/mol. This ketone is utilised as a building block in organic synthesis, specifically in reactions such as aromatic bromination and the preparation of fused heterocycles. It is also employed in biochemical research as a potential regulatory site-directed reagent. Available from Tech Serve Solutions with an assay of 95%.
- IUPAC
- Bromomethyl ethyl ketone
Organic Synthesis Reagent
1-Bromo-2-butanone serves as a valuable reagent in organic synthesis, notably for aromatic bromination when used in conjunction with sodium hydride in DMSO. It is also instrumental in the microwave-assisted preparation of various fused heterocycles.
Biochemical Research Tool
This compound has been utilised in biochemical studies, such as its use as a potential regulatory site-directed reagent for specific residues on enzymes like pyruvate decarboxylase.
Ketone Building Block
As a functionalised ketone, 1-Bromo-2-butanone is a versatile building block for constructing more complex organic molecules within research and development settings.
| Molecular weight | 151.00 |
|---|---|
| Linear formula | C2H5COCH2Br |
| Assay | 95% |
| Boiling point | 105 °C/150 mmHg(lit.) |
| Density | 1.479 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.465(lit.) |
| Storage temperature | −20°C |
| Contains / stabiliser | ~5% calcium carbonate as stabilizer |
| Application | 1-Bromo-2-butanone (bromomethyl ethyl ketone) was used as a potential regulatory site-directed reagent for the residue C221 on pyruvate decarboxylase1. It was also used as a reagent for aromatic bromination with sodium hydride in DMSO2 and in a microwave-assisted preparation of fused heterocycles3. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 68 °C / 154.4 °F |
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromo-2-butanone used for?
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1-Bromo-2-butanone is used as a reagent in organic synthesis, including aromatic bromination and the preparation of fused heterocycles, as well as in biochemical research as a site-directed reagent.
What is the CAS number and chemical formula for 1-Bromo-2-butanone?
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The CAS number for 1-Bromo-2-butanone is 816-40-0, and its linear chemical formula is C2H5COCH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bromo-2-butanone with a purity of 95% assay. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 1-Bromo-2-butanone be handled safely?
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1-Bromo-2-butanone is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be used, and handling should occur in a well-ventilated area.
Is 1-Bromo-2-butanone a controlled substance?
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The provided data does not indicate that 1-Bromo-2-butanone is a controlled substance. Please refer to your local regulations for definitive information.
How is 1-Bromo-2-butanone packed and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging for chemical compounds like 1-Bromo-2-butanone for secure and compliant international shipment.
How can I request a quote or sample for 1-Bromo-2-butanone?
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To request a quote or sample for 1-Bromo-2-butanone, please contact our sales team through the details provided on the Tech Serve Solutions website.
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