(3R,4R)-3,4-Bis(diphenylphosphino)-1-benzylpyrrolidine

CAS 99135-95-2C35H33NP2Chemical Synthesis

(3R,4R)-3,4-Bis(diphenylphosphino)-1-benzylpyrrolidine (CAS: 99135-95-2) is a chiral phosphine ligand with the molecular formula C35H33NP2 and a molecular weight of 529.59 g/mol. It is widely employed in asymmetric synthesis and chemical catalysis, particularly as a privileged ligand in transition metal-catalyzed reactions. Its specific stereochemistry enables high enantioselectivity in various synthetic transformations, making it a valuable tool for the preparation of chiral molecules.

IUPAC: (+)-N-Benzyl-(3R,4R)-bis(diphenylphosphino)pyrrolidine,(3R,4R)-1-Benzyl-3,4-bis-diphenylphosphanyl-pyrrolidine,catASium® D(R)
Synonyms: 99135-95-2C35H33NP2(+)-N-Benzyl-(3R,4R)-bis(diphenylphosphino)pyrrolidine(3R,4R)-1-Benzyl-3,4-bis-diphenylphosphanyl-pyrrolidinecatASium® D(R)

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(3R,4R)-3,4-Bis(diphenylphosphino)-1-benzylpyrrolidine (C35H33NP2) — chemical structure, CAS 99135-95-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentscatASium

01 /Applications

Asymmetric Catalysis

This compound serves as a key chiral ligand in transition metal-catalyzed asymmetric reactions, facilitating the synthesis of enantiomerically enriched products.

Organic Synthesis

It is utilized in various organic synthesis methodologies where stereocontrol is crucial, contributing to the efficient construction of complex chiral molecules.

Chiral Ligand

As a diphosphine ligand, it can coordinate with metal centers to form active catalysts for enantioselective transformations.

02 /Properties

Molecular weight	529.59
Empirical formula	C35H33NP2
Assay	≥97% (HPLC)
Optical purity	ee: ≥98% (HPLC)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305IF IN EYES

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

99135-95-2

Beilstein registry

3636084

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (3R,4R)-3,4-Bis(diphenylphosphino)-1-benzylpyrrolidine primarily used for?

This compound is primarily used as a chiral ligand in asymmetric synthesis and catalysis, enabling the enantioselective formation of chemical products.

What is the CAS number and molecular formula for this compound?

The CAS number is 99135-95-2 and the empirical formula is C35H33NP2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound with an assay of ≥97% (HPLC) and an optical purity of ee: ≥98% (HPLC). It is supplied as a research or technical grade material and is not represented as USP, BP, or EP grade.

What are the safety and handling considerations for this chemical?

This compound is classified as a Warning. It causes serious eye irritation (H319). In case of contact with eyes, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do, and continue rinsing (P305 + P351 + P338). If eye irritation persists, seek medical advice (26).