1,5-Diacetylindoline
1,5-Diacetylindoline (CAS 16078-35-6) is a chemical compound with the molecular formula C12H13NO2 and a molecular weight of 203.24 g/mol. This indoline derivative serves as a valuable building block in organic synthesis. Its applications include use as a reactant in α-arylation reactions and in the preparation of various pharmaceutical intermediates and research compounds, such as receptor antagonists and openers.
- Synonyms
- C12H13NO2
α-Arylation Reactions
1,5-Diacetylindoline is employed as a reactant in the facilitation of α-arylation reactions, contributing to the formation of complex organic structures.
Pharmaceutical Intermediate Synthesis
It serves as a key reactant in the synthesis of compounds investigated for their potential as 5-HT1B receptor antagonists.
KCNQ2 Opener Agents
This compound is utilised in the preparation of specific acrylamides, which are explored for their properties as KCNQ2 opener agents.
Photoreleasing Agents
1,5-Diacetylindoline is a reactant in the synthesis of certain 1-acyl-7-nitroindolines studied for their function as L-glutamate photoreleasing agents.
| Molecular weight | 203.24 |
|---|---|
| Empirical formula | C12H13NO2 |
| Assay | 97% |
| Application | • Reactant for α-arylation reactions1• Reactant for preparation of 5-HT1B receptor antagonists2• Reactant for synthesis of N-(1-benzo[1,3]dioxol-5-yl)ethyl-, N-[1-(2,3-dihydro-benzofuran-5-yl)ethyl-, and N-[1-(2,3-dihydro-1H-indol-5-yl)ethylacrylamides as KCNQ2 opener agents3• Reactant for preparation of 1-acyl-7-nitroindolines as L-glutamate photoreleasing agents in cerebellar granule neurons4 |
| Melting point | 137-141 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,5-Diacetylindoline used for?
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1,5-Diacetylindoline is used as a reactant in organic synthesis, including α-arylation reactions, and in the preparation of various pharmaceutical intermediates and research compounds.
What are the CAS number and formula for 1,5-Diacetylindoline?
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The CAS number is 16078-35-6 and the empirical formula (Hill notation) is C12H13NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,5-Diacetylindoline with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for 1,5-Diacetylindoline?
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1,5-Diacetylindoline is a Warning substance that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). It is recommended to use a dust mask type N95, eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
Can Tech Serve Solutions export 1,5-Diacetylindoline?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 1,5-Diacetylindoline.
How can I request a quote or sample of 1,5-Diacetylindoline?
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Please contact our sales department to request a quote or sample of 1,5-Diacetylindoline.
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