1-(5-Chloro-2-hydroxyphenyl)-1,3-butanedione
1-(5-Chloro-2-hydroxyphenyl)-1,3-butanedione (CAS 65897-66-7) is a chlorinated aromatic 1,3-diketone with the linear formula ClC6H3(OH)COCH2COCH3 (C10H9ClO3) and a molar mass of 212.63 g/mol. Supplied as a crystalline organic building block (melting point 112-116 degC), it serves chiefly in chemical synthesis and pharmaceutical-intermediate research, where its reactive 1,3-dicarbonyl and ortho-hydroxyaryl groups enable heterocycle and chelate formation. Tech Serve Solutions offers it to laboratory and manufacturing customers worldwide.
- Synonyms
- 1-(5-Chloro-2-hydroxyphenyl)-1,3-butanedione5'-Chloro-2'-hydroxyacetoacetophenone1-(5-Chloro-2-hydroxyphenyl)butane-1,3-dioneClC6H3(OH)COCH2COCH3MFCD00235254CAS 65897-66-7
Organic building block
Used as a C10 carbonyl building block in multistep organic synthesis. The combination of a 1,3-diketone and an ortho-hydroxy chlorophenyl ring provides several reactive sites for selective functionalisation.
Pharmaceutical intermediate research
Employed as an intermediate and reference compound in pharmaceutical and medicinal-chemistry research programmes. It is supplied for research and manufacturing use, not as a finished drug substance.
Heterocycle synthesis
The 1,3-dicarbonyl motif is a classical precursor for constructing heterocyclic rings such as pyrazoles, isoxazoles and chromones through condensation and cyclisation reactions.
Coordination and chelation chemistry
As a 1,3-diketone bearing an adjacent phenolic hydroxyl, it can act as a chelating ligand toward metal ions, supporting coordination-chemistry and materials studies.
Laboratory reagent
Functions as a fine-chemical reagent and reference standard for analytical and method-development work in research laboratories.
| Molecular weight | 212.63 |
|---|---|
| Linear formula | ClC6H3(OH)COCH2COCH3 |
| Melting point | 112-116 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(5-Chloro-2-hydroxyphenyl)-1,3-butanedione used for?
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It is used mainly as an organic building block and intermediate in chemical synthesis and pharmaceutical-intermediate research. Its 1,3-diketone and ortho-hydroxyaryl groups make it useful for heterocycle synthesis, chelation chemistry and as a laboratory reagent.
What is the CAS number and molecular formula of 1-(5-Chloro-2-hydroxyphenyl)-1,3-butanedione?
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The CAS number is 65897-66-7. The linear formula is ClC6H3(OH)COCH2COCH3, corresponding to the molecular formula C10H9ClO3 with a molecular weight of 212.63 g/mol. Its MDL number is MFCD00235254 and the reported melting point is 112-116 degC.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research/technical-grade fine chemical and organic building block. A specific assay value is confirmed on the certificate of analysis for each batch; we do not represent it as USP, BP or EP pharmacopoeial grade. Please request the current specification for your intended use.
What are the safety and handling requirements for this compound?
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It is classified under GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow precautionary advice P261 and P305+P351+P338. It carries Water Hazard Class WGK 3 in Germany. Always consult the Safety Data Sheet before use.
How is 1-(5-Chloro-2-hydroxyphenyl)-1,3-butanedione packed, shipped and exported?
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It is packed as a solid in suitable laboratory and bulk containers, sealed and labelled in line with GHS requirements, and shipped with full documentation including a certificate of analysis and Safety Data Sheet. Tech Serve Solutions exports worldwide and tailors pack sizes and transport arrangements to your order and destination requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name or CAS number 65897-66-7, your required quantity and grade, and your delivery location. We will respond with availability, specification, lead time and a formal quotation, and can arrange samples where appropriate.
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